24461-32-3

Basic information

• Product Name: FUMARIC-2,3-D2 ACID
• Synonyms: FUMARIC-D2 ACID, 98 ATOM % D;(2E)-but-2-enedioic acid;FUMARIC-2,3-D2 ACID;FUMARIC ACID (2,3-D2);fumaric-D2 acid
• CAS NO: 24461-32-3
• Molecular Formula: C₄H₄O₄
• Molecular Weight: 118.08
• Product Categories: Alphabetical Listings;E-F;Stable Isotopes
• Mol File: 24461-32-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 299-300 °C (subl.)(lit.)
• Boiling Point: 355.482°C at 760 mmHg
• Flash Point: 230℃
• Appearance: /
• Density: 1.525g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: FUMARIC-2,3-D2 ACID(CAS DataBase Reference)
• NIST Chemistry Reference: FUMARIC-2,3-D2 ACID(24461-32-3)
• EPA Substance Registry System: FUMARIC-2,3-D2 ACID(24461-32-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-36
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 24461-32-3(Hazardous Substances Data)

Usage

Uses

Fumaric Acid-d2 is the isotope labelled analog of Fumaric Acid. Fumaric acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.

InChI:InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+/i1D,2D

Upstream product

• 63995-70-0 trisodium tris(3-sulfophenyl)phosphine 
• 142-45-0 Acetylenedicarboxylic acid 
• 23057-98-9 dimethyl fumaric(2,3-²H₂) acid ester 

Downstream Products

• 23057-98-9 dimethyl fumaric(2,3-²H₂) acid ester 

Relevant articles and documents

New insight into the pyruvate decarboxylase-catalysed formation of lactaldehyde from H-D exchange experiments: A 'water proof' active site

Pyruvate decarboxylase from Saccharomyces cerevisiae catalyses the formation of lactaldehyde from sodium glyoxylate and acetaldehyde. By using deuteriated sodium glyoxylate (sodium [2-2H]glyoxylate monohydrate) as a substrate it was verified that the lactaldehyde formed retains the deuterium atom. The implications of the observed result for the enzyme mechanism are discussed in the light of conclusions derived from recent molecular modelling studies.

ORGANIC CHEMISTRY IN WATER (PART V) NUCLEOPHILIC ADDITION OF WATER-SOLUBLE PHOSPHINES ON ACTIVATED ALKYNES: AN EFFICIENT SYNTHESIS OF NEW VINYLPHOSPHONIUM SALTS AND OF SPECIFICALLY DEUTERATED OLEFINS.

Triphenylphosphine m-trisulfonate 1 and triphenylphosphine m-monosulfonate 2 react in water with activated alkynes R-CC-A (A = CO2H, CO2R1, COR2, CHO) affording new vinylphosphonium salts or vinylphosphine oxides or alkenes depending on the pH of the aqueous solution and on the nature of the substituent R.The reactions of 1 or 2 with alkynes bearing an electron-acceptor substituent R give rise to the corresponding trans disubstituted olefins.Specifically mono or dideuterated alkenes are thus obtained in good yields by sequential use of H2O-D2O.When R = H or Alkyl, vinylphosphonium salts or vinylphosphine oxides are quantitatively produced respectively in acidic or in neutral solution.

A NEW SYNTHESIS OF VINYLPHOSPHONIUM SALTS. APPLICATION FOR DEUTERIUM LABELING(1)

Nucleophilic additions of water-soluble phosphines on γ-alcynic acids afford new vinylphosphonium salts which are easily transformed into specifically deuteriated olefins or phosphine oxides by using sequentially H2O or D2O.