23057-98-9Relevant articles and documents
New insight into the pyruvate decarboxylase-catalysed formation of lactaldehyde from H-D exchange experiments: A 'water proof' active site
Lobell, Mario,Crout, David H. G.
, p. 1577 - 1581 (1996)
Pyruvate decarboxylase from Saccharomyces cerevisiae catalyses the formation of lactaldehyde from sodium glyoxylate and acetaldehyde. By using deuteriated sodium glyoxylate (sodium [2-2H]glyoxylate monohydrate) as a substrate it was verified that the lactaldehyde formed retains the deuterium atom. The implications of the observed result for the enzyme mechanism are discussed in the light of conclusions derived from recent molecular modelling studies.
A Highly Efficient and Large-Scale Synthesis of (2S,3S)-- and (2S,3R)-Aspartic Acids via an Immobilized Aspartase-Containing Microbial Cell System
Lee, Kang-Man,Ramalingam, Kondareddiar,Son, Jong-Keun,Woodard, Ronald W.
, p. 3195 - 3198 (1989)
This paper describes the preparation and utilization of an immobilized aspartase-containing Escherichia coli system for the large-scale synthesis of (2S,3S)-- and (2S,3R)-aspartic acids from the appropriately labeled fumaric acids in >95percent isolated yield, with >97percent deuterium incorporation at the C-3 center and optically pure at both the C-2 and C-3 centers.
Deuterium Substituted Fumarate Derivatives
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Paragraph 0102; 0103, (2014/07/08)
Provided is a compound of formula (I): or a pharmaceutically acceptable salt thereof. Also provided is a method of activating the Nrf2 pathway, comprising contacting cells with a sufficient amount of a compound of formula (I) described herein. Also provided is a method of treating a neurodegenerative disease, comprising administering to a subject in need of treatment for the neurodegenerative disease an effective amount of a compound of formula (I) described herein.
