24467-44-5

Upstream product

• 24467-41-2 (E)-3-benzylideneflavanone 
• 118-93-4 o-hydroxyacetophenone 
• 100-52-7 benzaldehyde 
• 487-26-3 Flavanone 

Downstream Products

• 109754-33-8 C₂₃H₁₈N₂O₂ 
• 109754-33-8 C₂₃H₁₈N₂O₂ 
• 5453-03-2 2-phenyl-3-benzoyl-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Structure-cytotoxic activity relationship of 3-arylideneflavanone and chromanone (E,Z isomers) and 3-arylflavones

The E,Z-isomers of 3-arylidene substituted flavanone, chromanone and 3-aryl substituted flavone derivatives were tested in vitro for their cytotoxic activity against three cancer cell lines (HL-60, NALM-6, WM-115) and normal cell line (HUVEC). It was observed that substitution at C3 position led to significant enhance in cytotoxicity. Isomeric configuration of 3-arylideneflavanones had an influence on the cytotoxic potential. Multiple regression analysis combined with variable selection by genetic algorithm was used to model relationships between molecular descriptors and the cytotoxic activity. The most accurate QSAR models were based on a combination between energy of LUMO, experimental value of log P and partial charge on carbonyl oxygen (δO2).

Supported choline hydroxide (ionic liquid) as heterogeneous catalyst for aldol condensation reactions

Choline hydroxide was used as a basic catalyst for aldol condensation reactions to produce new C-C bonds between several ketones and aldehydes. Choline supported on MgO exhibits higher TOF values than other well known basic catalysts in these reactions.

A Novel and Convenient One-pot Synthesis of 3-Benzylidene-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-ones

A novel and convenient one-pot synthesis of 3-benzylidene-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-ones from hydroxyacetophenones is described.It was also observed that the title compounds are the major side products in the Claisen-Schmidt chalcone synthesi

FLAVANOID PART 7 : A NOVEL PHOTOSYNTHESIS OF 3-α-HYDROXYBENZYLFLAVONES FROM 3-ARYLIDENEFLAVANONES

E-3 Arylideneflavanones 4 on UV irradiation using quartzware undergo auto-oxidation to 3-aroylflavones 5.Photolysis using pyrex filter in the presence of iodoform furnishes 3-α-hydroxybenzylflavones indicating the intermediacy of the hydroperoxide 11 and form a new general method for the synthesis of these compounds not available by other routes.

NOVEL ONE POT CONVENIENT SYNTHESIS OF 3- BENZYLIDENE-2-PHENYL-2,3-DIHYDRO-4H-1-BENZOPYRAN-4-ONES

A novel one pot good yield synthesis of 3-benzylidene-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-ones by the condensation of o-hydroxyacetophenones with aromatic aldehydes has been described and the new compounds were identified by their chemical, analytical and spectroscopic data.

A Novel One-Pot Synthesis of 3-Benzal-2,3-dihydro-4H-1-benzopyran-4-ones

3-Benzal-2,3-dihydro-4H-1-benzopyran-4-ones (8-14) have been synthesizedin good yields by a novel one-pot method involving condensation of hydroxyacetophenones with aromatic aldehydes.The reaction is general and has a biogenetic significance.