24476-16-2Relevant academic research and scientific papers
TRNA SYNTHETASE INHIBITORS
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Paragraph 00459, (2019/07/30)
Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.
Importance of the Aromatic Ring in Adrenergic Amines. 7. Comparison of the Stereoselectivity of Norepinephrine N-Methyltransferase for Aromatic vs. Nonaromatic Substrates and Inhibitors
Rafferty, Michael F.,Wilson, David S.,Monn, James A.,Krass, Polina,Borchardt, Ronald T.,Grunewald, Gary L.
, p. 1198 - 1204 (2007/10/02)
Some nonaromatic analogues of amphetamine and α-methylbenzylamine were prepared and evaluated as competitive inhibitors of norepinephrine N-methyltranspherase (NMT).All of the nonaromatic analogues were significantly more active than their aromatic counte
Fragmentation of Homoallylic Alkoxides. Thermolysis of Potassium 2-Substituted Bicyclooct-5-en-2-alkoxides
Snowden, Roger L.,Schulte-Elte, Karl H.
, p. 2193 - 2202 (2007/10/02)
Thermolysis of the potassium 2-substituted bicyclooct-5-en-2-alkoxides derived from alcohols 2-17 at 90-120 deg C in hexamethylphosphoric triamide affords unsaturated ketones resulting from allylic bond cleavage.The mechanistic and synthetic aspects of this anionic fragmentation are discussed with reference to the formation of 1-(3'-cyclohexenyl)-2-alkanones 18-28 via initial heterolytic C(1),C(2)-bond cleavage in the substrate alkoxide and regioselective, intramolecular protonation of the resultant transient allylic anion.
