2450-25-1

Usage

Derivative of indole

Heterocyclic aromatic compound The compound is based on an indole structure, which is a type of aromatic compound containing a nitrogen atom in the ring.

Methoxy group at the 5-position

A methoxy (-OCH3) group is attached to the 5th position of the indole ring, which is one of the carbon atoms in the ring.

Phenylmethoxy group at the 4-position

A phenylmethoxy (-OCH2Ph) group is attached to the 4th position of the indole ring, which is another carbon atom in the ring.

Methoxyphenylindole derivative

The presence of both methoxy and phenylmethoxy groups on the indole ring makes 1H-Indole, 5-methoxy-4-(phenylmethoxy)- a derivative of methoxyphenylindole.

Used in organic synthesis and medicinal chemistry

The compound is used as a building block or intermediate in the synthesis of other organic compounds, and is also studied for potential therapeutic applications in medicinal chemistry.

Pharmacological properties

The properties of the compound that determine its potential effects and uses in medicine are currently being studied for therapeutic applications.

Upstream product

• 142072-75-1 2-Allyl-1-azido-3-benzyloxy-4-methoxy-benzene 
• 148674-70-8 4-benzyloxy-5-methoxyindole-2-carboxaldehyde 
• 636-93-1 5-nitroguaiacol 
• 100-39-0 benzyl bromide 
• 142072-73-9 2-allyl-3-benzyloxy-4-methoxy-1-nitrobenzene 
• 142072-72-8 2-allyl-6-methoxy-3-nitrophenol 
• 142072-71-7 3-allyloxy-4-methoxynitrobenzene 
• 142072-74-0 2-Allyl-3-benzyloxy-4-methoxy-phenylamine 

Downstream Products

• 154810-51-2 4-benzyloxy-5-methoxyindole-3-carbaldehyde 
• 148674-71-9 4-benzyloxy-5-methoxy-1-methylindole 
• 154810-55-6 4-benzyloxy-5-methoxy-1-methylindole-3-carbaldehyde 
• 49635-16-7 5-methoxy-1H-indol-4-ol 

Relevant academic research and scientific papers

Synthesis of the Topoisomerase II Inhibitor BE 10988

The naturally occuring indolequinone BE 10988 1, an inhibitor of topoisomerase II, has been synthesised in an overall yield of 28percent.

Synthesis of the Naturally Occurring Indolequinone BE 10988, an Inhibitor of Topoisomerase II

A short synthesis (28percent overall yield) of the naturally occuring indolequinone BE 10988 1 is described.The synthesis starts from the 4-benzyloxy-5-methoxyindole and involves, as key steps, the use of chlorosulfonyl isocyanate to introduce the amide side-chain into the indole 3-position, followed by thioamide formation and construction of the thiazole ring using a Hantzsch reaction.

Use of indole derivative for dyeing keratin materials, tinctorial compositions, new compounds and dyeing process

Process for dyeing keratin fibers by using derivatives of formula: STR1 where: R1 =H, lower alkyl or SiR11 R12 R13 ; R2 and R3, which may be identical or different, =H, alkyl, carboxyl, alkoxycarbonyl or --COOSiR11 R12 R13 ; R4 to R7, which may be identical or different, =H or an O--Z group, where Z=H, C1 -C20 alkyl, aralkyl, formyl, C2 -C20 acyl, C3 -C20 alkenyl, --SiR11 R12 R13, --P(O)(OR8)2, R8 OSO2 ; or a heterocycle which may contain a P(O)(OR8) or CR9 R10 group; with the reservation that at least two of R4 to R7 denotes OZ or form a ring, and that at least one of R4 or R7 represents OZ; R8 and R9 =H, lower alkyl; R10 =alkoxy, mono- or dialkylamino; R11, R12 and R13, which may be identical or different, are alkyl groups; or their alkali metal, alkaline-earth metal, ammonium and amine salts.

A regioselective entry to azirino[1,2-a]indole derivatives by epoxidation/Staudinger reaction of o-allylphenyl azides

On treatment with triphenylphosphine epoxy-azides 2 form azirino[1,2-a]indoles 6 via Staudinger type aminocyclization reaction.