24504-14-1

Upstream product

• 57440-68-3 2-methyl-2-(3-oxopentyl)-1,3-cyclohexanedione 
• 115304-68-2 (S)-1,3-Dimethyl-2-[(1E,3Z)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexa-1,3-dienyl]-4-oxo-cyclohex-2-enecarboxylic acid methyl ester 
• 186581-53-3 diazomethane 
• 131134-38-8 (R)-6-(t-Butyldimethylsiloxymethyl)-3-ethoxy-2,6-dimethyl-2-cyclohexen-1-one 
• 115260-44-1 (2S,4aS,5S)-2,3,4,4a,5,6,7,8-octahydro-1,4a-dimethyl-5-tetrahydropyranyloxy-2-naphthyl benzoate 
• 115260-42-9 (2S,4aS,5S)-2,3,4,4a,5,6,7,8-octahydro-1,4a-dimethyl-5-tetrahydropyranyloxy-2-naphthols 
• 115260-50-9 (1S,4S)-methyl 4-benzoyloxy-1,3-dimethyl-2-(3-oxo-1E-butenyl)-2-cyclohexene-1-carboxylate 
• 115260-48-5 (1S,4S)-methyl-4-benzoyloxy-1,3-dimethyl-2-(3-oxobutyl)-2-cyclohexenecarboxylate 
• 115260-47-4 (2S,4aS,6RS)-2,3,4,4a,5,6,7,8-octahydro-6-hydroxy-1,4a,6-trimethyl-5-oxo-2-naphthyl benzoate 
• 115260-46-3 (2S,4aS,6RS)-2,3,4,4a,5,6,7,8-octahydro-1,4a-dimethyl-5-oxo-2-naphthyl benzoate 
• 115260-45-2 (-)-(2S,4aS)-2,3,4,4a,5,6,7,8-octahydro-1,4a-dimethyl-5-oxo-2-naphthyl benzoate 
• 123505-35-1 Benzoic acid (2S,4aS,5S)-5-hydroxy-1,4a-dimethyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-yl ester 
• 115260-41-8 (4aS,5S)-4,4a,5,6,7,8-hexahydro-1,4a-dimethyl-5-tetrahydropyranyloxy-2(3H)-naphthalenone 
• 34160-87-7 (+)-(S)-methyl 1,3-dimethyl-4-oxo-2-(3-oxo-1E-butenyl)-2-cyclohexene-1-carboxylate 

Relevant academic research and scientific papers

APPLICATION OF BIOCHEMICAL METHODS IN ENANTIOSELECTIVE SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS

Enzymes as well as yeasts were used in enantioselective syntheses of bioregulators such as hormones and semiochemicals.Lipases and esterases were employed in achieving optical resolution, conversion of meso-compounds to optically active compounds, and macrolactonization.Lactase effected glucosidation of a phenolic hydroxy ketone without any protection of the functional groups.Yeasts provided a variety of optically active hydroxy esters and ketones, which served as versatile non-racemic chiral building blocks.

TOTAL SYNTHESIS OF (+)-METHYL TRISPORATE B, FUNGAL SEX HORMONE

The enantioselective synthesis of (+)-methyl trisporates B (2 and 4) has been described.The chiral enedione 11, which was prepared by asymetric aldol condensation of the prochiral triketone 12, was converted to α-hydroxyketone 9 via the oxobenzoate 10.Cle