245115-25-7 Usage
Uses
Used in Peptide Synthesis:
(1S,2R)-Boc-2-amino-1-cyclopentanecarboxylic acid is utilized as a protected amino acid in the synthesis of peptides. The Boc-group protects the amino group from unwanted side reactions, allowing for the stepwise construction of peptide chains in a controlled manner.
Used in Protein Synthesis:
In the field of protein synthesis, (1S,2R)-Boc-2-amino-1-cyclopentanecarboxylic acid is employed as a building block for the assembly of proteins. Its protected nature ensures that the amino acid can be incorporated into the growing protein chain without interference from the unprotected amino group.
Used in Laboratory Research:
(1S,2R)-Boc-2-amino-1-cyclopentanecarboxylic acid is also used in various laboratory applications, where its unique structure and protected nature make it a valuable tool for studying the properties and interactions of amino acids and peptides.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (1S,2R)-Boc-2-amino-1-cyclopentanecarboxylic acid may be used as a starting material or intermediate in the synthesis of complex molecules, such as drug candidates, that require the incorporation of cyclopentane-containing amino acids. The Boc protection allows for the selective introduction of this functionality into the molecule without affecting other reactive groups.
Check Digit Verification of cas no
The CAS Registry Mumber 245115-25-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,5,1,1 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 245115-25:
(8*2)+(7*4)+(6*5)+(5*1)+(4*1)+(3*5)+(2*2)+(1*5)=107
107 % 10 = 7
So 245115-25-7 is a valid CAS Registry Number.
245115-25-7Relevant academic research and scientific papers
(S,S)-trans-cyclopentane-constrained peptide nucleic acids. A general backbone modification that improves binding affinity and sequence specificity
Pokorski, Jonathan K.,Witschi, Mark A.,Purnell, Bethany L.,Appella, Daniel H.
, p. 15067 - 15073 (2007/10/03)
Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modifie
Synthesis and structural characterization of helix-forming β-peptides: Trans-2-aminocyclopentanecarboxylic acid oligomers
Appella, Daniel H.,Christianson, Laurie A.,Klein, Daniel A.,Richards, Michele R.,Powell, Douglas R.,Gellman, Samuel H.
, p. 7574 - 7581 (2007/10/03)
Synthetic protocols and circular dichroism (CD) spectra are reported for a series of oligomers of (R,R)-trans-2-aminocyclopentanecarboxylic acid (trans-ACPC). The two longest oligomers, a hexamer and an octamer, have also been examined crystallographicall
Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors
Noeteberg, Daniel,Branalt, Jonas,Kvarnstroem, Ingemar,Classon, Bjoern,Samuelsson, Bertil,Nillroth, Ulrika,Danielson, U. Helena,Karlen, Anders,Hallberg, Anders
, p. 7975 - 7984 (2007/10/03)
The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described.
