245116-19-2Relevant academic research and scientific papers
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
Lu, Tianbao,Markotan, Thomas,Coppo, Frank,Tomczuk, Bruce,Crysler, Carl,Eisennagel, Stephen,Spurlino, John,Gremminger, Lisa,Soll, Richard M.,Giardino, Edward C.,Bone, Roger
, p. 3727 - 3731 (2007/10/03)
Through structure-based drug design and parallel synthesis, we have discovered a novel series of nonpeptidic phenyl-based thrombin inhibitors using oxyguanidines as guanidine bioisosteres. These compounds have been found to be highly potent, highly selective, and orally bioavailable.
Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
-
, (2008/06/13)
The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I:wherein X is O or NH, L is -O- or -SO2-, and R1-R4, R9-R19, Ra, Rb, Rc, Y, Z, n and m are set forth in the specification, as well as hydrat
