245123-89-1Relevant academic research and scientific papers
Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics
Li, Min,Lin, Zhaolan,Johnson, Michael E.
, p. 1957 - 1962 (1999)
Based on the structure of the thrombin-NAPAP complex, phosphinic dipeptide mimetics were designed as novel thrombin inhibitors. Synthesis and evaluation of these inhibitors revealed a promising lead with an IC50 of 0.6 μM.
