Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics

DOI: 10.1016/S0960-894X(99)00319-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1957 - 1962 (1999)

Update date:2022-08-02

Topics:

Authors:

Li, Min Li, Min

Lin, Zhaolan

Johnson, Michael E.

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Article abstract of DOI:10.1016/S0960-894X(99)00319-4

Based on the structure of the thrombin-NAPAP complex, phosphinic dipeptide mimetics were designed as novel thrombin inhibitors. Synthesis and evaluation of these inhibitors revealed a promising lead with an IC₅₀ of 0.6 μM.

Full text of DOI:10.1016/S0960-894X(99)00319-4

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