24513-10-8

Upstream product

• 637-81-0 ethyl-2-azidoacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 129801-37-2 1-(4-Chloro-phenylamino)-6,7-dimethoxy-isoquinoline-3-carboxylic acid ethyl ester 
• 129801-38-3 1-(4-Fluoro-phenylamino)-6,7-dimethoxy-isoquinoline-3-carboxylic acid ethyl ester 
• 129801-36-1 Ethyl 6,7-dimethoxy-1-(4-tolylamino)isoquinoline-3-carboxylate 
• 129801-51-0 2-(4-Chloro-phenyl)-4-[1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-4H-oxazol-5-one 
• 25349-37-5 (Z)-2-phenyl-4-(3,4-dimethoxybenzylidene)-(4H)-1,3-oxazol-5-one 
• 129801-35-0 C₃₁H₃₀NO₄P 

Relevant academic research and scientific papers

Regiospecific electrocyclization of β-arylvinyl ketenimines. Formal syntheses of the alkaloid from marine origin aaptamine

Preparation of 6,7-dimethoxy-1-methyl-8-nitroisoquinoline and 6,7-dimethoxy-1-methylisoquinoline, used as precursors in the synthesis of the alkaloid aaptamine, is reported. The method is based on the regiospecific electrocyclization of the appropriate β-arylvinyl ketenimine available by aza-Wittig reaction of the corresponding vinyl iminophosphorane with (trimethylsilyl)ethenone.

Preparation and Thermal Ring-closure of β-Aryl Vinyl Carbodi-imides: Synthesis of Isoquinoline Derivatives

Reaction of the iminophosphoranes (7)-(9), derived from α-azidocinnamates and triphenylphosphine, with aromatic isocyanates gives either 1-arylaminoisoquinoline-3-carboxylates (10)-(12) or the corresponding carbodi-imides (14)-(18) which by thermal treatm