24513-10-8Relevant articles and documents
Regiospecific electrocyclization of β-arylvinyl ketenimines. Formal syntheses of the alkaloid from marine origin aaptamine
Molina, Pedro,Vidal, Angel,Barquero, Isidora
, p. 1199 - 1202 (2007/10/03)
Preparation of 6,7-dimethoxy-1-methyl-8-nitroisoquinoline and 6,7-dimethoxy-1-methylisoquinoline, used as precursors in the synthesis of the alkaloid aaptamine, is reported. The method is based on the regiospecific electrocyclization of the appropriate β-arylvinyl ketenimine available by aza-Wittig reaction of the corresponding vinyl iminophosphorane with (trimethylsilyl)ethenone.