25349-37-5

Upstream product

• 129801-35-0 C₃₁H₃₀NO₄P 
• 98-88-4 benzoyl chloride 
• 495-69-2 Hippuric Acid 
• 67101-90-0 1,2-dimethoxy-4-<<(4-methylphenyl)imino>methyl>benzene 
• 27895-67-6 N-(3,4-dimethoxybenzylidene)aniline 
• 82363-24-4 (3,4-dimethoxybenzylidene)-(4-methoxyphenyl)amine 
• 38608-18-3 4-chloro-N-(3,4-dimethoxyphenyl)methylenebenzenamine 
• 82363-27-7 3,4-dimethoxybenzal-4-bromoaniline 
• 1199-01-5 2-phenylazlactone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 24513-10-8 ethyl α-azido-3,4-dimethoxycinnamate 

Downstream Products

• 54837-86-4 4-[(3,4-dimethoxy-phenyl)-ethoxy-methyl]-2-phenyl-4H-oxazol-5-one 
• 1273258-29-9 1,4:3,6-dianhydro-2,5-bis-[2-benzamido-(Z)-3,4-dimethoxycinnamamido]-2,5-dideoxy-L-iditol 
• 1328630-14-3 [Pd2(2-phenyl-4-(4,5-dimethoxybenzylidene-κC2)-(4H)-1,3-oxazol-5-one(1-))2(μ-pyruvato)2] 
• 1328630-12-1 [Pd2(2-phenyl-4-(4,5-dimethoxybenzylidene-κC2)-(4H)-1,3-oxazol-5-one(1-))2(μ-chloroacetato)2] 
• 1328630-22-3 [Pd2(2-phenyl-4-(4,5-dimethoxybenzylidene-κC2)-(4H)1,3-oxazol-5-one(1-))2(μ-trifluoroacetato)2] 
• 1328630-58-5 [Pd2(2-phenyl-4-(4,5-dimethoxybenzylidene-κC2)-(4H)-1,3-oxazol-5-one(1-))2(μ-acetato)2] 
• 58486-87-6 (Z)-4-(3,4-dimethoxybenzylidene)-2-phenyl-1H-imidazol-5(4H)-one 
• 2460-33-5 3,4-dimethoxyphenylpyruvic acid 
• 21873-14-3 4-(4,5-dimethoxy-2-nitro-benzylidene)-2-phenyl-4H-oxazol-5-one 
• 139596-91-1 N-{4-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 136713-00-3 3-(1H-Benzoimidazol-2-ylamino)-5-[1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-3,5-dihydro-imidazol-4-one 
• 86818-92-0 5-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-3-(4-morpholin-4-yl-phenyl)-2-phenyl-3,5-dihydro-imidazol-4-one 
• 138973-06-5 1,4-Bis(5'-(3,4-dimethoxybenzylidene)-2'-phenyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 121507-90-2 5-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-3-(5,6-diphenyl-[1,2,4]triazin-3-ylamino)-2-phenyl-3,5-dihydro-imidazol-4-one 

Relevant academic research and scientific papers

Design, Synthesis, and Antimicrobial Activity of Novel Fluorine-Containing Imidazolones

Abstract: A simple synthetic protocol have been developed for the preparation of novelN-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl)-N′-phenylthiourea derivatives by the reaction of4-benzylidene-2-phenyl-4,5-dihydro-1,3-oxazol-5-ones with N

Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi-Substituted Δ2-Pyrrolines and Their Cytotoxicity

An efficient, metal free approach to synthesize multi-substituted Δ2-pyrroline derivatives by mild base catalyzed cyclocondensation of malononitrile with Erlenmeyer azlactones via 1,2 addition was developed. The modularity of this reaction was used to assemble a range of poly-substituted pyrrolines. Further, synthesized products were screened for cytotoxic properties on different cancer cell lines such as A549 (Human lung adenocarcinoma cells), HeLa (Human cervical adenocarcinoma cells), Jurkat (Human chronic myeloid leukemia cells) and K562 (Human leukemic T cell Lymphoblast cells). Among the synthesized library of compounds, 6f and 6q displayed potent cytotoxic activity.

Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights

In this work, we present the synthesis and biological evaluation of novel series of diamide-based benzenesulfonamides 5a-h as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IX and XII. The target tumor-associated i

Orthopalladation of GFP-Like Fluorophores Through C–H Bond Activation: Scope and Photophysical Properties

The luminescence of oxazolones R1-C6H4CH=CC(O)O-CN(R2) (1a–1j) and imidazolones R1-C6H4CH=CC(O)NR3CN(R2) (1k–1q) has been examined. The new GFP-like imidazo

Stereoselective Intermolecular [2 + 2] Cycloadditions of Erlenmeyer-Pl?chl Azlactones Using Visible Light Photoredox Catalysis

The first report of the preparation of symmetric and nonsymmetric diaminotruxinic derivatives through the photoredox [2 + 2] cycloadditions of Erlenmeyer azlactones is described, affording the desired compounds in high regio- and diastereocontrol (only head-to-head coupling). Mechanistic studies by DFT suggest that the reaction proceeds through a neutral photocatalytic pathway.

Microwave-assisted efficient synthesis of azlactones using zeolite NaY as a reusable heterogeneous catalyst

The efficient preparation of azlactones in the presence of zeolite NaY has been reported. This heterogeneous catalyst was used for efficient synthesis of azlactone derivatives with Ac2O as a condensing agent under microwave irradiation and solvent-free co

New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof

PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.

Microwave-assisted efficient and mild synthesis of azlactone derivatives

(Formula presented) A convenient and mild procedure for the synthesis of azlactones in the presence of catalytic amounts of calcium hydrogen phosphate as a green, inexpensive and environmentally benign catalyst has been demonstrated. The present protocol is operationally simple and offers some advantages such as good yields, short reaction time, simple work-up, low cost and reusability of catalyst, which makes this method mild and eco-friendly.

Resolving Electronic Transitions in Synthetic Fluorescent Protein Chromophores by Magnetic Circular Dichroism

The detailed electronic structures of fluorescent chromophores are important for their use in imaging of living cells. A series of green fluorescent protein chromophore derivatives is examined by magnetic circular dichroism (MCD) spectroscopy, which allows the resolution of more bands than plain absorption and fluorescence. Observed spectral patterns are rationalized with the aid of time-dependent density functional theory (TDDFT) computations and the sum-over-state (SOS) formalism, which also reveals a significant dependence of MCD intensities on chromophore conformation. The combination of organic and theoretical chemistry with spectroscopic techniques also appears useful in the rational design of fluorescence labels and understanding of the chromophore's properties. For example, the absorption threshold can be heavily affected by substitution on the phenyl ring but not much on the five-member ring, and methoxy groups can be used to further tune the electronic levels.

A convenient synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones under solvent-assisted grinding

A facile and effective approach for the synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones has been developed. Under solvent-assisted grinding in the presence of 2,4,6-trichloro-1,3,5-triazine, catalytic triphenylphosphine, and sodium carbonate, dehydrati