24522-30-3

Basic information

• Product Name: 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide
• Synonyms: 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide;AcetaMide, 2-cyano-N-[4-(trifluoroMethyl)phenyl]-;Leflunomide Impurity H;Leflunomide EP Impurity H;2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
• CAS NO: 24522-30-3
• Molecular Formula: C₁₀H₇F₃N₂O
• Molecular Weight: 228.18
• Mol File: 24522-30-3.mol
• Article Data: 23

Chemical Properties

• Melting Point: 145-147℃
• Boiling Point: 386.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.375±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.63±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide(24522-30-3)
• EPA Substance Registry System: 2-cyano-N-[4-(trifluoromethyl)phenyl]acetamide(24522-30-3)

Safety Data

• Hazardous Substances Data: 24522-30-3(Hazardous Substances Data)

Usage

Uses

2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2.

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 372-09-8 cyanoacetic acid 
• 16130-58-8 cyanoacetic acid chloride 
• 105-56-6 ethyl 2-cyanoacetate 
• 621-03-4 cyanoacetanilide 
• 2926-29-6 Langlois reagent 
• 36140-83-7 1-cyanoacetyl-3,5-dimethylpyrazole 

Downstream Products

• 136186-08-8 (Z)-2-Cyano-3-hydroxy-3-(4-trifluoromethoxy-phenyl)-N-(4-trifluoromethyl-phenyl)-acrylamide 
• 136186-01-1 (Z)-2-Cyano-3-(4-fluoro-phenyl)-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide 
• 136186-04-4 (Z)-3-(3-Chloro-phenyl)-2-cyano-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide 
• 136186-10-2 (Z)-2-Cyano-3-(4-cyano-phenyl)-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide 
• 163451-81-8 teriflunomide 
• 1146220-16-7 C₁₇H₁₄F₃N₅O 
• 183945-57-5 2-cyano-3-cyclopentyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide 
• 183945-55-3 2-cyano-3-cyclopropyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide 
• 136185-97-2 2-cyano-3-hydroxy-3-phenyl-N-(4-(trifluoromethyl)phenyl)acrylamide 
• 171197-18-5 2-cyano-3-hydroxy-4-methyl-N-(4-(trifluoromethyl)phenyl)pent-2-enamide 
• 183945-56-4 2-cyano-3-cyclobutyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide 
• 1263303-84-9 (E)-N-hydroxy-2-oxo-2-((4-(trifluoromethyl)phenyl)amino)acetimidoyl cyanide 
• 1327339-17-2 2-(1-((2-chlorothiazol-5-yl)methyl)imidazolidin-2-ylidene)-2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide 
• 1327339-09-2 2-(1-((6-chloropyridin-3-yl)methyl)imidazolidin-2-ylidene)-2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide 

Relevant articles and documents

Preparation method of aniline para-trifluoromethylated derivative

The invention discloses a preparation method of an aniline para-trifluoromethylated derivative. The method comprises the following steps: sequentially adding an aniline derivative, 4, 5-dichlorofluorescein, potassium persulfate and sodium trifluoromethanesulfinate into a glass reaction tube, and reacting at room temperature (23-25 DEG C) under 40W blue LED (light-emitting diode) by taking dimethyl sulfoxide as a solvent to obtain the aniline para-trifluoromethylated derivative. According to the invention, the aniline derivative is used as an initiator, and the raw materials are easily available and various; products obtained by the method disclosed by the invention have various types and can be directly applied to modification of drug molecules; and meanwhile, the synthesis route is safe and easy to implement, the cost is low, the reaction operation and post-treatment process are simple, the selectivity is good, the side reaction is few, and the amplification reaction can be carried out.

NEW MALONITRILE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1-R2 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Preparation process of continuous-flow teriflunomide

To the preparation process, cyanoacetic acid is used as a starting material, cyanoacetyl chloride is prepared by chlorination, and a tertamine intermediate is synthesized by cyanacetyl chloride and p-trifluoromethylaniline, and an intermediate is synthesized with acetyl chloride. The invention has high safety. The utility model has the advantages of low cost, low energy consumption and high production yield.