24526-91-8Relevant academic research and scientific papers
Copper-Catalyzed Cyclization for Access to 6H-Chromeno[4,3-b]quinolin-6-ones Employing DMF as the Carbon Source
Weng, Yiyi,Zhou, Hao,Sun, Chen,Xie, Yuanyuan,Su, Weike
, p. 9047 - 9053 (2017/09/11)
The first example of the copper-catalyzed cyclization of 4-(phenylamino)-2H-chromen-2-ones employing the N-methyl moiety of DMF as the source of the methine (CH) group has been developed, providing an efficient synthetic pathway to access novel functional
Synthesis, Cytotoxic Evaluation, and In Silico Studies of 4-Substituted Coumarins
Kaur, Prabhjot,Gill, Rupinder Kaur,Singh, Gagandip,Bariwal, Jitender
, p. 1519 - 1527 (2016/09/23)
Two series of coumarins possessing the aniline- and heterocyclic ring at 4thposition have been synthesized and evaluated for their in vitro cytotoxic activity against MCF-7 cancer cell line in MTT assay. Structure activity relationship (SAR) studies reveal that the electron donor group at position-8 of coumarin played an important role in cytotoxic activity. Compound VIId showed the potent cytotoxic activity followed by compound Xa with IC50= 6.25 and 6.50 μM, respectively. A docking study has also been carried out for the most potent compound to get an insight into molecular interactions with p50 subunit of NF-κB protein.
A Novel Transformation of 4-Arylaminocoumarins to 6H-1-Benzopyranoquinolin-6-ones Under Vilsmeier-Haack Conditions
Tabakovic, K.,Tabakovic, I.,Ajdini, N.,Leci, O.
, p. 308 - 310 (2007/10/02)
4-Aryl and 4-alkylaminocoumarins 1 were prepared by reacting of 4-hydroxycoumarin and an appropriate amine.The reaction of 1 with phosphorousoxychloride/dimethylformamide led to 6H-1-benzopyranoquinoline-6-one derivatives 2 in very good yields, whi
