2453-51-2

Basic information

• Product Name: 2-Benzimidazolebutanol(7CI,8CI)
• Synonyms: 2-Benzimidazolebutanol(7CI,8CI)
• CAS NO: 2453-51-2
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24
• Product Categories: BENZIMIDAZOLE
• Mol File: 2453-51-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 160-162 °C(Solv: tetrahydrofuran (109-99-9))
• Boiling Point: 434.7±28.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• PKA: 11.93±0.10(Predicted)
• CAS DataBase Reference: 2-Benzimidazolebutanol(7CI,8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzimidazolebutanol(7CI,8CI)(2453-51-2)
• EPA Substance Registry System: 2-Benzimidazolebutanol(7CI,8CI)(2453-51-2)

Safety Data

• Hazardous Substances Data: 2453-51-2(Hazardous Substances Data)

Upstream product

• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 39650-64-1 4-(1H-benzo[d]imidazol-2-yl)butan-1-amine 
• 5622-83-3 1,2,3,4-tetrahydro-pyrido[1,2-a]benzimidazole 

Relevant articles and documents

Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines

Benzimidazoles represent common chemical moieties in bioactive compounds. The synthesis of this heterocycle often involves a condensation of an ortho-phenylenediamine with a carboxylic acid derivative. The observed dialkylation of the starting ortho-phenylenediamine is avoided by opening of lactones or lactams. This strategy can directly yield 1 H-benzimidazoles substituted at the 2-position by a functionalized chain. We present herein a study of the effect of different electron-withdrawing or electron-donating groups at the 4-position of ortho-phenylenediamines on the opening of lactones or lactams to synthesize benzimidazol-2-yl alkanols and benzimidazol-2-yl alkylamines.