245364-47-0

Upstream product

• 5455-59-4 2-Nitrobenzenesulfonamide 
• 100-39-0 benzyl bromide 
• 198572-71-3 N-(tert-butoxycarbonyl)-2-nitrobenzenesulfonamide 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 42116-44-9 N-tert-butoxycarbonylbenzylamine 
• 42060-32-2 N-benzyl-2-nitrobenzenesulfonamide 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

HEAVY-NITROGENIZED NITROBENZENESULFONAMIDE, ITS DERIVATIVE AND PRODUCTION METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a heavy-nitrogenized nitrobenzenesulfonamide derivative and an efficient production method thereof. SOLUTION: The heavy-nitrogenized nitrobenzenesulfonamide compound is represented by general formula [2]. An amino group of

N-carboalkoxy-2-nitrobenzenesulfonamides: A practical preparation of N- Boc-, N-Alloc-, and N-Cbz-protected primary amines

N-Carboalkoxy-2-nitrobenzenesulfonamides, readily prepared by acylation of 2-nitrobenzenesulfonamide (o-NsNH2), can be alkylated by either conventional or Mitsunobu protocols. Since the o-nosyl group can be deprotected under mild conditions, a variety of N-carboalkoxy derivatives of primary amines may be prepared in excellent yields from the corresponding alcohols and/or halides. In addition, allyloxycarbonyl (Alloc), t- butoxycarbonyl (t-Boc), and benzyloxycarbonyl (Cbz) groups can be deprotected in the presence of the o-nosyl group, allowing the resultant N-alkylated 2- nitrobenzenesulfonamides to be used for further preparation of secondary amines.