245366-66-9

Upstream product

• 21040-45-9 Cinnamyl acetate 
• 170943-24-5 dimethyl (1-acetamido-2-oxopropyl)phosphonate 

Downstream Products

• 245366-72-7 dimethyl (2S,3S)-[1-(N-acetylamino)-2-hydroxy-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate 
• 245366-73-8 dimethyl (2S,3R)-[1-(N-acetylamino)-2-hydroxy-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate 

Relevant academic research and scientific papers

Enantioselective construction of quaternary α-carbon centers on α-amino phosphonates via catalytic asymmetric allylation

(equation presented) Asymmetric allylation of α-acetamido β-keto phosphonates was promoted, in the presence of potassium tert-butoxide as a base, by a palladium catalyst prepared from [Pd(π-allyl)(cod)]BF4 and (R)-BINAP and gave the corresponding α-alkyl α-amino phosphonic acid derivatives with 65-88% ee. Diastereoselective reduction of the carbonyl group in the product was accomplished by NaBH4 or Bu4NBH4. The diastereoselection in the reduction was reversed by choice of solvent.