245408-79-1Relevant academic research and scientific papers
OXINDOLE DERIVATIVE AS FEEDING CONTROL AGENT
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Page/Page column 25, (2008/12/06)
Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. (In the formula, R3 represents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; W1 and W2 independently represent a single bond or methylene; R7 and R8 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.)
Cyclobutanone photoadducts of HCN and malononitrile: useful intermediates for the synthesis of C-nucleosides
Mladenova, Gabriela,Lee-Ruff, Edward
, p. 2787 - 2789 (2008/02/03)
Photochemistry of cyclobutanones in the presence of HCN or malononitrile give photoadducts derived from oxacarbene insertion into C-H. These intermediates are useful for the preparation of C-nucleosides by structural elaboration of the CN groups.
Photocycloelimination of α,α-dichlorocyclobutanones
Ramnauth, Jailall,Lee-Ruff, Edward
, p. 1245 - 1248 (2007/10/03)
Direct irradiation of a series of α,α-dichlorocyclobutanones in benzene solutions results in photocycloelimination to give 1,1-dichloroalkenes in yields ranging from 30-65%. The α,α-dichlorocyclobutanones were formed in good yields from the [2+2] cycloaddition of the terminal olefins with dichloroketene. This two-step sequence formally represents a "metathesis" of two olefinic functions and provides an easy access to functionalized 1,1-dichloroalkenes. Irradiation of the dichlorocyclobutanones in the solid state led to poor yields of 1,1-dichloroalkenes and polymeric mixtures, however, photoreactions performed in zeolites gave similar yields as those run in benzene solutions.
