245425-39-2Relevant academic research and scientific papers
Quinolones as serine protease inhibitors
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Page/Page column 49, (2010/02/10)
The invention discloses quinolinones which display inhibitory effects on serine proteases such as factor Xa, thrombin and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically accept
Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa
Willardsen, J. Adam,Dudley, Danette A.,Cody, Wayne L.,Chi, Liguo,McClanahan, Thomas B.,Mertz, Thomas E.,Potoczak, Ronald E.,Narasimhan, Lakshmi S.,Holland, Debra R.,Rapundalo, Stephen T.,Edmunds, Jeremy J.
, p. 4089 - 4099 (2007/10/03)
Factor Xa (FXa) has materialized as a key enzyme for the intervention of the blood coagulation cascade and for the development of new antithrombotic agents. FXa is the lone enzyme responsible for the production of thrombin and therefore is an attractive t
