2454396-80-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4,7-trichloro-8-fluoropyrido[4,3-d]pyrimidine is used as a key intermediate in the synthesis of new drugs for various therapeutic applications. Its unique structure and reactivity make it a valuable component in the development of novel pharmaceutical compounds.
Used in Agrochemical Development:
2,4,7-trichloro-8-fluoropyrido[4,3-d]pyrimidine is used as a building block in the creation of new agrochemicals, such as pesticides and herbicides. Its potential to form stable and effective compounds makes it a promising candidate for use in agricultural applications.
Used in Organic Synthesis:
2,4,7-trichloro-8-fluoropyrido[4,3-d]pyrimidine is used as a versatile reagent in organic synthesis, allowing for the formation of a wide range of chemical products. Its unique structure and reactivity contribute to the synthesis of complex molecules and compounds.
Used in Material Science:
2,4,7-trichloro-8-fluoropyrido[4,3-d]pyrimidine is used as a component in the development of new materials with specific properties, such as high thermal stability or unique electronic characteristics. Its potential applications in material science could lead to advancements in various industries, including electronics and aerospace.

Upstream product

• 628691-93-0 2-chloro-3-fluoro-pyridine-4-carboxylic acid 
• 1354223-71-4 tert-butyl (2-chloro-3-fluoropyridin-4-yl)carbamate 
• 1227577-03-8 2-chloro-3-fluoro-pyridin-4-ylamine 
• 2454397-75-0 7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione 
• 2454397-74-9 ethyl 4-amino-6-chloro-5-fluoropyridine-3-carboxylate 
• 154012-18-7 2,4-dichloro-3-fluoropyridine-5-carboxylic acid 

Downstream Products

• 2621928-55-8 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol 
• 2621928-55-8 4-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol 

Relevant academic research and scientific papers

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12DInhibitor

KRASG12D, the most common oncogenic KRAS mutation, is a promising target for the treatment of solid tumors. However, when compared to KRASG12C, selective inhibition of KRASG12D presents a significant challenge due to the requirement of inhibitors to bind KRASG12D with high enough affinity to obviate the need for covalent interactions with the mutant KRAS protein. Here, we report the discovery and characterization of the first noncovalent, potent, and selective KRASG12D inhibitor, MRTX1133, which was discovered through an extensive structure-based activity improvement and shown to be efficacious in a KRASG12D mutant xenograft mouse tumor model.

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.