245487-45-0Relevant academic research and scientific papers
ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF MIRNA BIOGENESIS
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Page/Page column 37; fig.3, (2008/06/13)
The present disclosure relates to compounds and methods for inhibiting the formation of miRNAs that inhibit translation of one or more identified proteins. The compounds comprise antisense oligonucleotides targeting the ph-miRNA precursor of miRNAs.
ANTISENSE ANTIVIRAL COMPOUNDS AND METHODS FOR TREATING FOOT AND MOUTH DISEASE
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Page/Page column 32; 10/10, (2008/06/13)
An antiviral antisense composition and method for treating foot-and-mouth disease virus (FMDV) in veterinary animals is disclosed. The composition contains an antisense compound that has a sequence effective to target at least 12 contiguous bases of an FM
Multimeric VLA-4 antagonists comprising polymer moieties
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Page/Page column 63, (2010/02/15)
Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
POLYETHYLENE GLYCOL CONJUGATES OF HETEROCYCLOALKYL CARBOXAMIDO PROPANOIC ACIDS
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Page/Page column 42; 83-84, (2008/06/13)
Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e
