245539-09-7

Basic information

• Product Name: 1,2-DICHLORO-3-ISOCYANOBENZENE
• Synonyms: HANSA ISN-0058;2,3-DICHLOROPHENYLISOCYANIDE;2,3-DICHLORPHENYLISOCYANIDE;1,2-DICHLORO-3-ISOCYANOBENZENE;Benzene, 1,2-dichloro-3-isocyano- (9CI)
• CAS NO: 245539-09-7
• Molecular Formula: C₇H₃Cl₂N
• Molecular Weight: 172.01
• Product Categories: ISONITRITE
• Mol File: 245539-09-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-DICHLORO-3-ISOCYANOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DICHLORO-3-ISOCYANOBENZENE(245539-09-7)
• EPA Substance Registry System: 1,2-DICHLORO-3-ISOCYANOBENZENE(245539-09-7)

Safety Data

• Hazardous Substances Data: 245539-09-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical Production:
1,2-Dichloro-3-isocyanobenzene is used as an intermediate in the chemical industry for the production of various chemical products. Its unique structure allows it to be a key component in the synthesis of a range of organic chemicals.
Used in Pesticide Production:
In the agricultural sector, 1,2-Dichloro-3-isocyanobenzene is used as a precursor in the manufacturing process of certain pesticides. Its chemical properties contribute to the development of effective pest control agents.
Used in Pharmaceutical Production:
1,2-DICHLORO-3-ISOCYANOBENZENE also finds application in the pharmaceutical industry, where it serves as a building block for the synthesis of specific pharmaceuticals. Its reactivity and functional groups make it a valuable component in the creation of medicinal compounds.
Safety and Environmental Considerations:
Given its classification as a hazardous substance, 1,2-Dichloro-3-isocyanobenzene requires careful handling to minimize its potential toxicity and environmental impact. Proper safety measures, including the use of personal protective equipment and adherence to regulatory guidelines, are essential when working with 1,2-DICHLORO-3-ISOCYANOBENZENE in any industrial application.

Upstream product

• 2666-78-6 2,3-dichlorophenyl isocyanide dichloride 
• 6327-47-5 2,3-dichloroformanilide 

Downstream Products

• 79944-89-1 N-(Bis[Dimethylamino]methylene)-N'-phenyl-4-morpholine carboxamidine 
• 75013-86-4 N-phenyl-2-<1-(2-pyridinyl)ethylidene>hydrazinecyrboselenoamide 
• 4426-68-0 phenyl isoselenocyanate 
• 104379-16-0 N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine 

Relevant articles and documents

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

Electrochemical generation of alkyl and aryl isocyanides

An efficient and widely applicable reagent-free method for the synthesis of alkyl and aryl isocyanides has been established. The electrochemical reduction of alkyl and aryl carbonimidoyl dichlorides under constant cathode potential leads to the corresponding isocyanides in almost quantitative yields. The availability of the starting materials, the mildness of the reaction conditions as well as the easy isolation of products are noteworthy, advantageous features of the procedure.

Process for the preparation of aryl isocyanide-dichlorides

An improved process for preparation of arylisocyanide dichloride by chlorinating N-arylformamide in the presence of thionyl chloride wherein the improvement comprises preparing the N-arylformamide by formylation of an arylamine having 6 to 12 aryl carbon