6327-47-5

Basic information

• Product Name: N-(2,3-dichlorophenyl)formamide
• CAS NO: 6327-47-5
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.0267
• Mol File: 6327-47-5.mol

Chemical Properties

• Boiling Point: 359.5°C at 760 mmHg
• Flash Point: 171.2°C
• Density: 1.46g/cm³
• Vapor Pressure: 2.37E-05mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: N-(2,3-dichlorophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dichlorophenyl)formamide(6327-47-5)
• EPA Substance Registry System: N-(2,3-dichlorophenyl)formamide(6327-47-5)

Safety Data

• Hazardous Substances Data: 6327-47-5(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 608-27-5 2,3-dichloroaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 65078-77-5 2,3-dichloro-6-nitroaniline 
• 69951-03-7 2,3-dichloro-4-nitroaniline 
• 245539-09-7 2,3-dichlorophenyl isocyanide 
• 105548-26-3 4-(2-Acetylamino-4-diethylamino-phenylazo)-2,3-dichloro-benzenesulfonic acid 
• 105547-88-4 4-(4-Amino-2-diethylamino-6-methyl-pyrimidin-5-ylazo)-2,3-dichloro-benzenesulfonic acid 
• 105548-07-0 2,3-Dichloro-4-(4,6-diamino-2-ethylsulfanyl-pyrimidin-5-ylazo)-benzenesulfonic acid 
• 105547-67-9 4-(5-Amino-3-methyl-1-phenyl-1H-pyrazol-4-ylazo)-2,3-dichloro-benzenesulfonic acid 
• 105565-53-5 2,3-dichloro-4-nitrobenzenesulphonic acid 
• 56978-58-6 4-Amino-2,3-dichloro-benzenesulfonic acid 
• 104310-89-6 (2,3-Dichloro-phenyl)-phosphoramidic acid diethyl ester 
• 2666-78-6 2,3-dichlorophenyl isocyanide dichloride 

Relevant articles and documents

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Efficient: N -formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst

Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP?SO3H) have been synthesized, well characterized and explored for the first time, as an efficient and recyclable catalyst for N-formylation of primary amines under mild reaction conditions. Exploiting the magnetic nature of Fe3O4, the prepared catalyst was readily recovered from the reaction mixture via an external magnet. The catalyst can be reused for up to six cycles without any substantial loss of catalytic activity. The cost effectiveness, simple methodology, wide substrate tolerance, excellent yield and easy work-up are the additional advantages of present catalytic system. This journal is

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.