245554-87-4Relevant academic research and scientific papers
Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa
Willardsen, J. Adam,Dudley, Danette A.,Cody, Wayne L.,Chi, Liguo,McClanahan, Thomas B.,Mertz, Thomas E.,Potoczak, Ronald E.,Narasimhan, Lakshmi S.,Holland, Debra R.,Rapundalo, Stephen T.,Edmunds, Jeremy J.
, p. 4089 - 4099 (2007/10/03)
Factor Xa (FXa) has materialized as a key enzyme for the intervention of the blood coagulation cascade and for the development of new antithrombotic agents. FXa is the lone enzyme responsible for the production of thrombin and therefore is an attractive t
Benzoxazinoes/benzothiazinones as serine protease inhibitors
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, (2008/06/13)
This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnornal thrombosis.
Quinoxalinones as serine protease inhibitors such as factor XA and thrombin
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, (2008/06/13)
This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
