245662-01-5

Basic information

• Product Name: 7-Tosyloxyindole-2-methanol
• Synonyms: 7-Tosyloxyindole-2-methanol
• CAS NO: 245662-01-5
• Molecular Weight: 317.365
• Mol File: 245662-01-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-Tosyloxyindole-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Tosyloxyindole-2-methanol(245662-01-5)
• EPA Substance Registry System: 7-Tosyloxyindole-2-methanol(245662-01-5)

Safety Data

• Hazardous Substances Data: 245662-01-5(Hazardous Substances Data)

Upstream product

• 126260-57-9 Ethyl 7-tosyloxyindole-2-carboxylate 

Downstream Products

• 245662-11-7 Methyl 4-methoxy-8-tosyloxy-β-carboline-1-carboxylate 
• 245662-10-6 4-Methoxy-8-tosyloxy-β-carboline-1-carboxamide 
• 245662-03-7 Ethyl [(7-tosyloxyindol-2-ylmethyl)amino]acetate 
• 245662-09-3 4-Methoxy-8-tosyloxy-β-carboline-1-carbonitrile 
• 245662-04-8 Ethyl [N-(7-tosyloxyindol-2-ylmethyl)-N-formylamino]acetate 
• 245662-12-8 4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde 
• 245662-05-9 2-Formyl-4-oxo-8-tosyloxy-1,2,3,4-tetrahydro-β-carboline 
• 245662-13-9 4-Methoxy-8-tosyloxy-1-vinyl-β-carboline 
• 245662-14-0 1-Ethyl-4-methoxy-8-tosyloxy-β-carboline 
• 245662-08-2 4-Methoxy-8-tosyloxy-β-carboline N-oxide 
• 245662-06-0 4-Methoxy-8-tosyloxy-β-carboline 
• 99964-78-0 picrasidine P 
• 100234-59-1 picrasidine I 
• 100234-62-6 picrasidine J 

Relevant articles and documents

Synthetic studies on indoles and related compounds. Part 46.1 First total syntheses of 4, 8-dioxygenated β-carboline alkaloids

Total syntheses of naturally occurring 4, 8-dioxygenated β-carboline alkaloids 2a, 2d, 2g, and 2h are described. The synthetic route involves two methodologies that we developed; (i) an improved Fischer indolization for the synthesis of a 7-oxygenated indole using a tosyl group for protection of the phenolic group, (ii) construction of a 4-methoxy-β-carboline skeleton by the C-3-selective cyclization of the C-2-substituent of the indole nucleus. The phenolic O-tosyl group of the β-carboline skeleton was successfully cleaved to the phenol by Na-anthracenide, and this phenol was methylated with TMSCH2N2.