245675-99-4Relevant academic research and scientific papers
Application of organolithium and related reagents in synthesis. XXVII.[1] Effect of the nucleophilic character of silyl enol ethers upon the conversion of 3-arylphthalides into 2-(1-Aryl-2-methoxycarbonyl) benzoic acids
Bieniek, Adam,Epsztajn, Jan,Kulikiewicz, Krystyna K.
, p. 667 - 677 (2007/10/03)
A convenient two step protocol preparation of the ortho-alkylated (by secondary substituent with the carbomethoxy group at the end of alkyl chain) aromatic carboxylic acids 6 from benzoic acids anilides 1 was developed, which exploited the reductive alkylation of phthalides 4 with silyl vinyl ethers 5a-b or silyl ketene acetals 5c-g as a key step, is described.
