245679-91-8

Basic information

• Product Name: 2,5-Pyrimidinedione, tetrahydro-4-methyl-1,3-bis(phenylmethyl)-, (4S)-
• CAS NO: 245679-91-8
• Molecular Formula: C19H20N2O2
• Molecular Weight: 308.38
• Mol File: 245679-91-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrimidinedione, tetrahydro-4-methyl-1,3-bis(phenylmethyl)-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrimidinedione, tetrahydro-4-methyl-1,3-bis(phenylmethyl)-, (4S)-(245679-91-8)
• EPA Substance Registry System: 2,5-Pyrimidinedione, tetrahydro-4-methyl-1,3-bis(phenylmethyl)-, (4S)-(245679-91-8)

Safety Data

• Hazardous Substances Data: 245679-91-8(Hazardous Substances Data)

Upstream product

• 65838-17-7 1,3-di-(N-benzylamino)-2-hydroxypropane 
• 100-46-9 benzylamine 
• 245679-89-4 1,3-dibenzyl-1,2,3,4,5,6-hexahydropyrimidine-2,5-dione 
• 245679-88-3 1,3-dibenzyl-1,2,3,4,5,6-hexahydro-5-hydroxypyrimidin-2-one 
• 245679-90-7 (2S)-1,3-dibenzyl-1,2,3,4,5,6-hexahydro-5-{[2-(methoxymethyl)pyrrolidin-1-yl]imino}pyrimidine-2-one 

Relevant articles and documents

A highly flexible route to 1,2,3,4,5,6-hexahydro-5-hydroxypyrimidin-2-ones as potential HIV protease inhibitors

The first asymmetric synthesis of potential HIV protease inhibitors of type II, III and IV is described. Key step of the synthesis is an auxiliary based stereoselective alkylation by means of the (R)-1-amino-2-methoxymethylpyrrolidine (RAMP)- / (S)-1-amino-2-methoxymethylpyrrolidine (SAMP)-hydrazone method starting from a readily available key building block, pyrimidin-2,5-dione (6). The synthesis is short and highly versatile in the choice of the substitution pattern as well as the absolute configuration of the alkylated 1,2,3,4,5,6-Hexahydro-5-hydroxypyrimidin-2-ones.