24569-60-6Relevant academic research and scientific papers
Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals
Wu, Fu-Peng,Li, Da,Peng, Jin-Bao,Wu, Xiao-Feng
supporting information, p. 5699 - 5703 (2019/08/01)
In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.
Catalytic C-H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand
Yang, Ke,Li, Qun,Liu, Yongbing,Li, Guigen,Ge, Haibo
supporting information, p. 12775 - 12778 (2016/10/13)
The direct arylation of aliphatic aldehydes has been established via Pd-catalyzed sp3 C-H bond functionalization in the presence of 3-aminopropanoic acids as transient directing groups. The reaction showed excellent functional group compatibility and chemoselectivity in which a predominant preference for functionalizing unactivated β-C-H bonds of methyl groups over others was achieved. In addition, C-H bonds of unactivated secondary sp3 carbons can also be functionalized. The extreme popularity and importance of aliphatic aldehydes would result in broad applications of this novel method in organic chemistry and medicinal sciences.
Asymmetric synthesis of novel α-amino acids with β-branched side chains
Zhang, Minsheng,Porte, Alex,Diamantidis, George,Sogi, Kimberly,Kubrak, Dennis,Resnick, Lynn,Mayer, Scott C.,Wang, Zheng,Kreft, Anthony F.,Harrison, Boyd L.
, p. 2401 - 2403 (2008/02/03)
An asymmetric synthesis of α-amino acids with novel β-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic β-branched sidechains for preparation of previously unknown α-amino acids.
The chemistry of alkylstrontium halide analogues: Barbier-type alkylation of imines with alkyl halides
Miyoshi, Norikazu,Ikehara, Daitetsu,Kohno, Tadashi,Matsui, Aki,Wada, Makoto
, p. 760 - 761 (2007/10/03)
The chemistry of alkylstrontium halide analogues was examined. In the presence of metallic strontium, the Barbier-type alkylation of imines with alkyl iodides proceeded smoothly at room temperature under an argon atmosphere to afford the corresponding alk
COMPLEX BASES. XIV. USE OF SODAMIDE CONTAINING COMPLEX BASES AS VERSATILE, INEXPENSIVE REAGENTS TO GENERATE CARBANIONS
Carre, M. C.,Ndebeka, G.,Riondel, A.,Bourgasser, P.,Caubere, P.
, p. 1551 - 1554 (2007/10/02)
It is shown that Complex Bases NaNH2-RONa are very efficient in carbanion preparations and allow alkylation of imines, aldehydes, 1,3-dithianes, dithioketals as well as methylsulfenylation of ketones.
