245729-74-2Relevant articles and documents
Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B
Laurin, Patrick,Ferroud, Didier,Klich, Michel,Dupuis-Hamelin, Claudine,Mauvais, Pascale,Lassaigne, Patrice,Bonnefoy, Alain,Musicki, Branislav
, p. 2079 - 2084 (2007/10/03)
The design, synthesis, and in vitro biological activity of a series of novel coumarin inhibitors of gyrase B is presented. Replacement of the 3- acylamino residue (3-NHCOR) of coumarin drags with reversed isosteres C(=O)R, C(=N-OR)R', COOR, CONHR and CONH
A CONCISE SYNTHESIS OF PATULIN FROM ARABINOSE
Gill, G. Bryon,Pattenden, Gerald,Stapleton, Alan
, p. 2875 - 2878 (2007/10/02)
Conversion of arabinose (5) to the protected ketone (7), followed by Wittig condensation to (9), acid catalysed cyclisation (to 10), and dehydration, provides a brief synthesis of the fungal metabolite patulin (1), produced by Penicillium and Aspergilius