24587-41-5

Basic information

• Product Name: H-PHE-TRP-OH
• Synonyms: n-l-phenylalanyl-l-tryptopha;phenylalanyltryptophan;L-PHENYLALANYL-L-TRYPTOPHAN;H-PHE-TRP-OH;L-Phe-L-Trp-OH;Nα-(L-Phenylalanyl)-L-tryptophan;Phe-Trp-OH;Phe-Trp
• CAS NO: 24587-41-5
• Molecular Formula: C₂₀H₂₁N₃O₃
• Molecular Weight: 351.4
• Mol File: 24587-41-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 688.3 °C at 760 mmHg
• Flash Point: 370.1 °C
• Appearance: /
• Density: 1.319 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.672
• Storage Temp.: -15°C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: H-PHE-TRP-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-TRP-OH(24587-41-5)
• EPA Substance Registry System: H-PHE-TRP-OH(24587-41-5)

Safety Data

• Hazardous Substances Data: 24587-41-5(Hazardous Substances Data)

Usage

Definition

ChEBI: A dipeptide formed from L-phenylalanine and L-tryptophan residues.

InChI:InChI=1/C20H21N3O3/c21-16(10-13-6-2-1-3-7-13)19(24)23-18(20(25)26)11-14-12-22-17-9-5-4-8-15(14)17/h1-9,12,16,18,22H,10-11,21H2,(H,23,24)(H,25,26)

Upstream product

• 35661-40-6 N-Fmoc L-Phe 
• 143824-78-6 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 73-22-3 L-Tryptophan 
• 3081-24-1 H-Phe-OEt 
• 4299-70-1 L-tryptophan methyl ester 
• 83522-39-8 N^α-(tert-butoxycarbonyl)-L-phenylalanyl-L-tryptophan methyl ester 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 83522-40-1 (tert-butoxycarbonyl)-L-phenylalanyl-L-tryptophan 

Downstream Products

• 77935-23-0 H-Asn-Phe-Phe-Trp-OH 
• 77935-22-9 Z-Asn-Phe-Phe-Trp-OH 

Relevant articles and documents

γ-Valerolactone (GVL): An eco-friendly anchoring solvent for solid-phase peptide synthesis

Due to the hazardous nature of CH2Cl2, regulatory authorities have imposed restrictions to minimize or even stop its use. It has therefore become imperative to identify environmentally benign solvents to replace it. Here we report on a bio derived solvent, γ-valerolactone, for the incorporation of the first amino acid onto p-alkoxybenzyl alcohol resin in solid-phase peptide synthesis. Satisfactory loading values (by a spectrophotometric method) were achieved. Furthermore, racemization and dipeptide formation were also checked and found to be acceptable.

Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction

Aminopeptidase from Streptomyces thermocyaneoviolaceus NBRC14271 was engineered into transaminopeptidase and used to catalyze an aminolysis reaction to give linear and cyclic dipeptides from cost-effective substrates such as the ester derivatives of amino