2460-49-3

Basic information

• Product Name: 4,5-DICHLOROGUAIACOL
• Synonyms: 4,5-DICHLOROGUAIACOL;PHENOL,2-METHOXY-4,5-DICHLORO-;4,5-dichloro-2-methoxy-phenol;4,5-Dichloro-2-(methyloxy)phenol
• CAS NO: 2460-49-3
• Molecular Formula: C₇H₆Cl₂O₂
• Molecular Weight: 193.03
• Mol File: 2460-49-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 72-73 °C
• Boiling Point: 276.73°C (rough estimate)
• Flash Point: 121.8°C
• Appearance: /
• Density: 1.3883 (rough estimate)
• Vapor Pressure: 0.00262mmHg at 25°C
• Refractive Index: 1.4590 (estimate)
• PKA: 8.58±0.23(Predicted)
• CAS DataBase Reference: 4,5-DICHLOROGUAIACOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLOROGUAIACOL(2460-49-3)
• EPA Substance Registry System: 4,5-DICHLOROGUAIACOL(2460-49-3)

Safety Data

• Hazardous Substances Data: 2460-49-3(Hazardous Substances Data)

Usage

General Description

4,5-Dichloroguaiacol is a chemical compound with the molecular formula C7H6Cl2O2. It is a chlorinated derivative of guaiacol, which is a natural organic compound found in wood smoke and creosote. 4,5-Dichloroguaiacol is used as an intermediate in the production of agrochemicals and pharmaceuticals. It has also been studied for its potential use as a diagnostic and therapeutic agent in cancer treatments. The compound is a white to light yellow solid with a slight odor and is soluble in organic solvents. It is also known to be a skin and eye irritant and should be handled with care. Overall, 4,5-Dichloroguaiacol is a versatile chemical with various industrial and medical applications.

InChI:InChI=1/C7H6Cl2O2/c1-11-7-3-5(9)4(8)2-6(7)10/h2-3,10H,1H3

Upstream product

• 90-05-1 2-methoxy-phenol 
• 120-80-9 benzene-1,2-diol 
• 77-78-1 dimethyl sulfate 
• 1120310-43-1 4-chloro-6,6-dimethoxycyclohexa-2,4-dienone 
• 16766-30-6 4-Chloroguaiacol 
• 3428-24-8 4,5-dichlorocatechol 
• 74-88-4 methyl iodide 

Downstream Products

• 56913-12-3 (4,5-dichloro-2-methoxy-phenoxy)-acetic acid 
• 91820-60-9 2-Methoxy-4,5-dichlor-phenoxy-essigsaeure-butylester 
• 91495-18-0 2-Methoxy-4,5-dichlor-phenoxy-essigsaeure-isopropylester 
• 91495-19-1 2-Methoxy-4,5-dichlor-phenoxy-essigsaeure-propylester 
• 93313-89-4 ω-<4.5-Dichlor-2-methoxy-phenoxy>-acetoveratron 
• 90793-90-1 2-Methoxy-4,5-dichlor-phenoxy-essigsaeure-methylester 
• 92244-14-9 2-Methoxy-4,5-dichlor-phenoxy-essigsaeure-aethylester 
• 92106-25-7 Glycolaldehyd-(4,5-dichlor-guajacyl)-aether-diaethyl-acetal 
• 85430-15-5 4,5-Dichloroguaiacol acetate 
• 57057-83-7 3,4,5-trichloroguaiacol 
• 85430-21-3 3,4,5-Trichloroguaiacol acetate 
• 1354200-94-4 2-((4,5-dichloro-2-methoxyphenoxy)methyl)oxirane 
• 1354200-67-1 2-(3-(4,5-dichloro-2-methoxyphenoxy)-2-hydroxypropyl)-6-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 93408-27-6 α-<3,4-Dimethoxy-phenyl>-aethylen-glykol-β-<4,5-dichlor-guajacyl>-aether 

Relevant articles and documents

Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols

o-Quinone monoketals participated in a 1,4-addition reaction with HCl furnishing m-chlorophenols in high yields. Several readily available o-quinone monoketals were selected to display the generality of this serendipitous and unprecedented reaction and the results are presented herein.

Chemical Compounds

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.