246023-58-5

Basic information

• Product Name: 1-cyano-1-(2-methyl-4-methoxyphenyl)propan-2-one
• Synonyms: 1-cyano-1-(2-methyl-4-methoxyphenyl)propan-2-one
• CAS NO: 246023-58-5
• Molecular Weight: 203.241
• Mol File: 246023-58-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-cyano-1-(2-methyl-4-methoxyphenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyano-1-(2-methyl-4-methoxyphenyl)propan-2-one(246023-58-5)
• EPA Substance Registry System: 1-cyano-1-(2-methyl-4-methoxyphenyl)propan-2-one(246023-58-5)

Safety Data

• Hazardous Substances Data: 246023-58-5(Hazardous Substances Data)

Upstream product

• 52289-56-2 1-(bromomethyl)-4-methoxy-2-methylbenzene 
• 141-78-6 ethyl acetate 
• 262298-02-2 2-(4-methoxy-2-methylphenyl)acetonitrile 

Downstream Products

• 1338727-86-8 8-chloro-3-(4-methoxy-2-methylphenyl)-2-methyl-5H,7H-6-thia-1,4,8a-triaza-s-indacene 
• 1338727-85-7 8-chloro-3-(4-methoxy-2-methylphenyl)-2-methyl-5H,7H-6-oxa-1,4,8a-triaza-s-indacene 
• 1338727-84-6 8-chloro-5-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydro-1H-1,4,7,7a-tetraaza-s-indacene 
• 1338727-83-5 8-chloro-5-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydro-1-thia-4,7,7a-triaza-s-indacene 
• 1338727-82-4 8-chloro-5-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydro-1-oxa-4,7,7a-triaza-s-indacene 
• 441056-87-7 8-chloro-3-(4-methoxy-2-methylphenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacene 
• 202579-74-6 DMP 904 

Relevant articles and documents

6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists

To identify an orally active corticotropin-releasing factor 1 receptor antagonist, a series of 6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives were designed, synthesized and evaluated. An in vitro study followed by in vivo and pharmacokinetic studies of these heterotricyclic compounds led us to the discovery of an orally active CRF1 receptor antagonist. The results of a structure-activity relationship study are presented.

TRICYCLIC AND HETEROCYCLIC DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT

Tri- heterocyclic compound of formula (I) wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR2, NR13, nitrogen, oxygen, sulfur etc.; A ring is carbocyclic ring, heterocyclic ring; R1 is alkyl, alkenyl,