24610-33-1

Usage

Uses

Used in Pharmaceutical Industry:
7-Methoxy-1H-indole-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential biological activities and pharmacological properties. It contributes to the development of new drugs and pharmaceutical products, enhancing their therapeutic efficacy and applications.
Used in Medicinal Chemistry Research and Development:
7-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID is utilized as an important substance in research and development within the field of medicinal chemistry. Its unique structure and properties make it a valuable tool for exploring novel drug candidates and understanding their mechanisms of action, thereby advancing the discovery of innovative therapeutic agents.

InChI:InChI=1/C10H9NO3/c1-14-8-4-2-3-6-5-7(10(12)13)11-9(6)8/h2-5,11H,1H3,(H,12,13)

Upstream product

• 84638-71-1 7-methoxy-1H-indole-2-carboxylic acid methyl ester 
• 20538-12-9 ethyl 7-methoxy-1H-indole-2-carboxylate 
• 591-31-1 3-methoxy-benzaldehyde 
• 82204-33-9 2-nitro-3-methoxy-α-(oxo)benzenoacetic acid 

Downstream Products

• 3189-22-8 7-methoxy-1H-indole 
• 109021-59-2 7-methoxy-1H-indole-3-carbaldehyde 
• 812652-85-0 7-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde 
• 812653-09-1 16-[7-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol 
• 1394078-55-7 (7-methoxy-1H-indol-2-yl)-(4-methyl-1,4-diazepan-1-yl)methanone 
• 53512-46-2 2-methyl-7-methoxy indole 

Relevant academic research and scientific papers

INDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME

An indole derivative represented by the following general formula (1) : wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents -(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT ALLERGIC RHINITIS

A method to treat allergic rhinitis is disclosed in which patients are administered certain indolyl compounds.

Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres

In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared, 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.