246137-75-7

Basic information

• Product Name: (1S,3R)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
• Synonyms: (1S,3R)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
• CAS NO: 246137-75-7
• Molecular Weight: 292.337
• Mol File: 246137-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1S,3R)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3R)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(246137-75-7)
• EPA Substance Registry System: (1S,3R)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(246137-75-7)

Safety Data

• Hazardous Substances Data: 246137-75-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 153-94-6 D-tryptophan 
• 14907-27-8 (R)-(+)-tryptophan methyl ester hydrochloride 

Relevant articles and documents

Microwave accelerated Pictet-Spengler reactions of tryptophan with ketones directed toward the preparation of 1,1-disubstituted indole alkaloids

Using the Pictet-Spengler reactions of tryptophan with aldehydes under acidic conditions at ambient temperature, diastereoisomers of 1,3-disubstituted-1,2,3,4-tetrahydro-β-carbolines could readily be furnished in short time (0.5-4 h) with good to excellent yields (50-98%). Though intrinsically slow in reaction rates, ketone reactions can be accelerated (from days to minutes) using microwaves in open vessels with high isolated yields (67-99%), making those carbolines feasible reaction intermediates for the synthesis of both natural and unnatural indole alkaloids. Preparation of two indole alkaloids, tetrahydro-β-carbolinediketopiperazines and tetrahydro-β-carbolinehydantoins, were briefly discussed. Graphical Abstract

Aryl substituted 1 H - pyrido [3, 4 - b] indole -3 - carboxylic acid methyl ester chiral separation of (by machine translation)

The invention discloses a toS- 1 - (2 - Tert-butyl phenyl) ethylamine is chiral resolving agent, one category of containing two chiral centers 1 - aryl - 1 H - pyrido [3, 4 - b] indole - 3 - carboxylic acid methyl ester non-enantiomers on chiral separation method. The method mainly through hydrolysis, split, dissociation, esterification and main experimental steps. The method has the high split yield, chiral resolving agent is easy to obtain, chiral reagent is easy to recycle, splitting effect is good and the like. (by machine translation)