246139-76-4

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex organic molecules, contributing to the development of new drugs.
Used in Agrochemical Industry:
2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE is used as an intermediate in the synthesis of agrochemicals for its role in creating compounds that can be used in the development of pesticides and other agricultural products.
Used in Organic Synthesis:
2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE is used as a chemical reagent in various organic synthesis reactions for its reactivity and ability to form new compounds with desired properties.
Safety Measures:
Due to its reactivity and potential health hazards, proper handling and storage of 2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE should follow safety measures to minimize risks.

Upstream product

• 98-51-1 4-tert-butyltoluene 
• 61024-94-0 2-bromo-4-tert-butyl-1-methylbenzene 

Downstream Products

• 349452-99-9 2-bromo-4-tert-butylmethoxymethylbenzene 
• 246139-77-5 2-bromo-4-(tert-butyl)benzaldehyde 
• 141-52-6 sodium ethanolate 
• 1383611-42-4 (1R,2R)-N,N-bis[4-(tert-butyl)-2-(tert-butylthio)benzylidene]-1,2-cyclohexanediamine 
• 1383612-01-8 4-(tert-butyl)-2-(tert-butylthio)benzaldehyde 
• 1332371-82-0 diethyl (2-bromo-4-tert-butylbenzyl)malonate 
• 1332371-88-6 2-(5-tert-butyl-2-ethyl-1H-inden-7-yl)-1,1,2,2-tetramethyl-N-(2-methylphenyl)disilanamine 
• 1332371-89-7 C₂₆H₃₉NSi₂ 
• 1332371-83-1 2-(2-bromo-4-tert-butylbenzyl)butanoyl chloride 
• 1355049-93-2 2-(2-bromo-4-tert-butylbenzyl)butanoic acid 
• 130840-94-7 4,4'-di-tert-butyl-2,2'-bis(chloromethyl)diphenylethane 
• 194665-97-9 {5-tert-Butyl-2-[2-(4-tert-butyl-2-hydroxymethyl-phenyl)-ethyl]-phenyl}-methanol 

Relevant academic research and scientific papers

Bis-Cyclometalated Indazole Chiral-at-Rhodium Catalyst for Asymmetric Photoredox Cyanoalkylations

A new class of bis-cyclometalated rhodium(III) catalysts containing two inert cyclometalated 6-tert-butyl-2-phenyl-2H-indazole ligands and two labile acetonitriles is introduced. Single enantiomers (>99 % ee) were obtained through a chiral-auxiliary-mediated approach using a monofluorinated salicyloxazoline. The new chiral-at-metal complex is capable of catalyzing the visible-light-induced enantioselective α-cyanoalkylation of 2-acyl imidazoles in which it serves a dual function as the chiral Lewis acid catalyst for the asymmetric radical chemistry and at the same time as the photoredox catalyst for the visible-light-induced redox chemistry (up to 80 % yield, 4:1 d.r., and 95 % ee, 12 examples).

Synthesis and Photophysical Properties of a 13,13′-Bibenzo[b]perylenyl Derivative as a π-Extended 1,1′-Binaphthyl Analog

A 13,13′-bibenzo[b]perylenyl derivative-an axially chiral π-extended compound in which two perylene subunits fused to 1,1′-binaphthyl scaffold-has been synthesized from 1,8-dibromophenanthrene using an anionic cyclodehydrogenation reaction in the presence

Cross-coupling strategy for the synthesis of diazocines

Ethylene bridged azobenzenes are novel, promising molecular switches that are thermodynamically more stable in the (Z) than in the (E) configuration, contrary to the linear azobenzene. However, their previous synthetic routes were often not general, and yields were poorly reproducible, and sometimes very low. Here we present a new synthetic strategy that is both versatile and reliable. Starting from widely available 2-bromobenzyl bromides, the designated molecules can be obtained in three simple steps.

The synthesis of lactone-bridged 1,3,5-triphenylbenzene derivatives as pi-expanded coumarin triskelions

Two triply lactone-bridged 1,3,5-triphenylbenzene derivatives with solubilizing moieties have been synthesized in five and six steps from commercially available starting materials. Compounds containing the 1,3,5-triphenylbenzene core with two atom bridges are relatively unknown. This new class of pi-expanded coumarins contain triskelion architectures and X-ray crystallographic studies of one of the triskelions indicates that the 1,3,5-triphenylbenzene core adopts a near-planar geometry. This is the only known example of a two atom-bridged 1,3,5-triphenylbenzene derivative to adopt a planar structure.

Asymmetric hydrogenation of ketones with H2 and ruthenium catalysts containing chiral tetradentate S2N2 ligands

Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. Copyright

Mono-indenyl transition metal compounds and polymerization therewith

This invention relates to transition metal compounds, catalyst sytems comprising said compounds and polymerization processes using such catalyst systems, where the transition metal compound is represented by the formula: or This invention also relates to process to produce such compounds.

Mono-Indenyl Transition Metal Compounds and Polymerization Therewith

This invention relates to transition metal compounds, catalyst systems comprising said compounds and polymerization processes using such catalyst systems, where the transition metal compound is represented by the formula: This invention also relates to process to produce such compounds.

METALLOCENE COMPOUNDS

A bridged metallocene compound of formula (I) wherein: M is an atom of a transition metal selected from those belonging to group 3, 4, or to the lanthanide or actinide groups in the Periodic Table of the Elements; X, equal to or different from each other,

Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides

The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role in regulating the function of sensory nerves. A growing body of evidence demonstrates the therapeutic potential of TRPV1 modulators, particularly in the management of pain. As a result of our screening efforts, we identified (E)-3-(4-tert- butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks the capsaicin-induced and pH-induced uptake of 45Ca2+ in TRPV1-expressing Chinese hamster ovary cells with IC50 values of 17 ± 5 and 150 ± 80 nM, respectively. In this report, we describe the synthesis and structure-activity relationship of a series of N-aryl cinnamides, the most potent of which (49a and 49b) exhibit good oral bioavailability in rats (Foral = 39% and 17%, respectively).

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.