24614-14-0

Basic information

• Product Name: 4(1H)-Pyrimidinone, 5-hydroxy-2-methyl- (8CI,9CI)
• Synonyms: 4(1H)-Pyrimidinone, 5-hydroxy-2-methyl- (8CI,9CI);2-Methyl-5-hydroxypyrimidine-4(3H)-one;5-Hydroxy-2-methylpyrimidin-4(1H)-one
• CAS NO: 24614-14-0
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.11334
• Product Categories: PYRIMIDINE
• Mol File: 24614-14-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 310 °C (decomp)
• Boiling Point: 276.4°Cat760mmHg
• Flash Point: 120.9°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 0.00286mmHg at 25°C
• Refractive Index: 1.619
• PKA: 8.88±0.50(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 5-hydroxy-2-methyl- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 5-hydroxy-2-methyl- (8CI,9CI)(24614-14-0)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 5-hydroxy-2-methyl- (8CI,9CI)(24614-14-0)

Safety Data

• Hazardous Substances Data: 24614-14-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H6N2O2/c1-3-6-2-4(8)5(9)7-3/h2,8H,1H3,(H,6,7,9)

Upstream product

• 91036-39-4 1-(5-hydroxy-2-methyl-4-pyrimidinylthio)-2-propanol 
• 1194-22-5 2-methyl-4,6-dihydroxypyrimidine 
• 60438-04-2 5-(benzyloxy)-2-methylpyrimidin-4-ol 
• 24611-14-1 5-hydroxy-2-methyl-4-pyrimidinethione 
• 91036-38-3 1-(5-hydroxy-2-methyl-4-pyrimidinylthio)-2-propanone 
• 35231-61-9 5-hydroxy-2-methyl-4-methylthiopyrimidine 
• 61675-94-3 ethyl (tetrahydropyranyloxy)acetate 
• 124-42-5 acetamidine hydrochloride 
• 109-94-4 formic acid ethyl ester 
• 60438-04-2 5-benzyloxy-2-methyl-3H-pyrimidin-4-one 
• 99170-32-8 2-methyl-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one 
• 53135-23-2 (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-carbamic acid ethyl ester 

Downstream Products

• 13421-99-3 3-Cyclohexyl-6-methyl-8-hydroxy-3.4-dihydro-2H-pyrimido<4.5-e>-1.3-oxazin 
• 946505-88-0 2-methyl-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidine 
• 36591-61-4 6-amino-5-hydroxy-2-methylpyrimidin-4(3H)-one 
• 13365-46-3 3-Benzyl-6-methyl-8-hydroxy-3.4-dihydro-2H-pyrimido<4.5-e>-1.3-oxazin 
• 5753-18-4 3.6-Dimethyl-8-hydroxy-3.4-dihydro-2H-pyrimido<4.5-e>-1.3-oxazin 

Relevant articles and documents

Properties of the OH adducts of hydroxy-, methyl-, methoxy-, and amino-substituted pyrimidines: Their dehydration reactions and end-product analysis

Reactions of hydroxyl radicals (OH) with 2-amino-4-methyl pyrimidine (AMP), 2-amino-4,6-dimethyl pyrimidine (ADMP), 2-amino-4-methoxy-6-methyl pyrimidine (AMMP), 2-amino-4-hydroxy-6-methyl pyrimidine (AHMP), 4,6-dihydroxy-2-methyl pyrimidine (DHMP), 2,4-d

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3- dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlogumine; and use of the derivatives and analogs for treating cancer.

An autoxidation study of C2 substituted pyrimidine amino reductones

Three pyrimidine derivatives (8a-c), differing from isouramil and divicine at C2, have been synthesized and their autoxidation rates measured spectrophotometrically. The autoxidation rates of all five pyrimidines (8a-c, isouramil and divicine) were correl