246166-35-8

Upstream product

• 108-24-7 acetic anhydride 
• 228254-23-7 4-amino-3-(2-bromo-4-isopropylphenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxamide 
• 246166-33-6 2-bromo-4-isopropylphenylisothiocyanate 
• 51605-97-1 2-bromo-4-isopropylaniline 

Downstream Products

• 1606178-58-8 6-((2-bromo-4-isopropylphenyl)amino)-2-methyl-5-(methylthio)pyrimidin-4(3H)-one 
• 1606178-59-9 6-((2-bromo-4-isopropylphenyl)amino)-5-(ethylthio)-2-methylpyrimidin-4(3H)-one 
• 1606178-64-6 N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine 
• 1606178-37-3 N⁴-(2-bromo-4-isopropylphenyl)-2-methyl-5-(methylthio)-N⁶,N⁶-dipropylpyrimidine-4,6-diamine 
• 1606178-38-4 N⁴-(2-bromo-4-isopropylphenyl)-N⁶,N⁶-diethyl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine 
• 1606178-39-5 N⁴-(2-bromo-4-isopropylphenyl)-N⁶,N⁶-bis(2-methoxyethyl)-2-methyl-5-(methylthio)pyrimidine-4,6-diamine 
• 1606178-40-8 N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine 
• 1606178-41-9 N⁴-(2-bromo-4-isopropylphenyl)-N⁶-butyl-N⁶-ethyl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine 
• 228254-24-8 3-(2-bromo-4-isopropyl-phenyl)-7-chloro-5-methyl-3H-thiazolo[4,5-d]pyrimidine-2-thione 

Relevant academic research and scientific papers

Synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands

Corticotropin releasing factor (CRF) is a neuropeptide hormone produced from the hypothalamus that controls the secretion of corticotropin (ACTH) from the anterior pituitary gland that, in turn, prompts the adrenal glands to secrete glucocorticoids. This

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.