246231-77-6 Usage
Uses
Used in Pharmaceutical Industry:
(S)-1-[(R)-2-(Dicyclohexylphosphino)-Ferrocenyl]EthylDicyclohexylPhosphine is utilized as a chiral ligand for the synthesis of chiral molecules and pharmaceuticals. Its unique configuration allows for selective interactions with certain substrates and transition metals, which is crucial in the production of enantiomerically pure compounds. This selectivity is particularly valuable in the development of single-enantiomer drugs, as it can lead to more effective and safer medications with fewer side effects.
Used in Chemical Catalysis:
In the field of chemical catalysis, (S)-1-[(R)-2-(Dicyclohexylphosphino)-Ferrocenyl]EthylDicyclohexylPhosphine serves as a ligand in transition metal catalysis. Its ability to coordinate with transition metals and facilitate selective reactions makes it an important component in various catalytic processes. This can lead to more efficient and cleaner chemical syntheses, reducing waste and improving the overall sustainability of chemical production.
Used in Asymmetric Synthesis:
(S)-1-[(R)-2-(Dicyclohexylphosphino)-Ferrocenyl]EthylDicyclohexylPhosphine is also employed in asymmetric synthesis, where it plays a critical role in the production of enantiomerically enriched compounds. Its chiral nature enables the creation of molecules with specific three-dimensional arrangements, which is essential for the biological activity of many pharmaceuticals and agrochemicals. This application is particularly relevant in the development of new drugs and the improvement of existing ones, as it can lead to more targeted and effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 246231-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,6,2,3 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 246231-77:
(8*2)+(7*4)+(6*6)+(5*2)+(4*3)+(3*1)+(2*7)+(1*7)=126
126 % 10 = 6
So 246231-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C31H51P2.C5H5.Fe/c1-25(32(26-15-6-2-7-16-26)27-17-8-3-9-18-27)30-23-14-24-31(30)33(28-19-10-4-11-20-28)29-21-12-5-13-22-29;1-2-4-5-3-1;/h14,23-29H,2-13,15-22H2,1H3;1-5H;/t25-;;/m0../s1
246231-77-6Relevant academic research and scientific papers
Rhodium-Catalyzed Asymmetric Allylation of Malononitriles as Masked Acyl Cyanide with Allenes: Efficient Access to β,γ-Unsaturated Carbonyls
Grugel, Christian P.,Breit, Bernhard
supporting information, p. 15223 - 15226 (2018/09/25)
A rhodium-catalyzed regio- and enantioselective intermolecular allylation of malononitriles as masked acyl cyanides (MAC) with terminal and symmetrical internal allenes is reported. A RhI/Josiphos catalytic system combined with subsequent oxidative degradation of the primary adducts enables a straightforward access to α-branched, β,γ-unsaturated carbonyl compounds. The present protocol exhibits perfect atom economy in the allylation step and is characterized by a great functional group compatibility. Furthermore, the use of α-substituted malononitriles allowed for the construction of all-carbon quaternary centers.
