246239-91-8Relevant articles and documents
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)
Norman, Bryan H.,Gruber, Joseph M.,Hollinshead, Sean P.,Wilson, Joseph W.,Starling, James J.,Law, Kevin L.,Self, Tracy D.,Tabas, Linda B.,Williams, Daniel C.,Paul, Donald C.,Wagner, Margaret M.,Dantzig, Anne H.
, p. 883 - 886 (2002)
Tricyclic isoxazoles were identified from a screen as a novel class of selective multidrug resistance protein (MRP1) inhibitors. From a screen lead, SAR efforts resulted in the preparation of LY 402913 (9h), which inhibits MRP1 and reverses drug resistanc
