246245-22-7Relevant academic research and scientific papers
CF3-Containing para-Quinone Methides for Organic Synthesis
Winter, Michael,Schütz, Roman,Eitzinger, Andreas,Ofial, Armin R.,Waser, Mario
supporting information, p. 3812 - 3817 (2020/04/15)
A new family of CF3-containing para-quinone methides (CF3-QMs) was systematically investigated for its suitability in organic synthesis. Addition of different nucleophiles gives access to target molecules with a benzylic CF3-containing stereogenic center straightforwardly. The electrophilicity parameter E of the prototypical CF3-QM 2,6-di-tert-butyl-4-(2,2,2-trifluoroethylidene)cyclohexa-2,5-dien-1-one was determined to be –11.68 according to the Mayr scale, making it one of the most reactive quinone methides known so far.
TiCl4-catalyzed friedel-crafts reaction of trifluoroacetaldehyde ethyl hemiacetal (TFAE)
Zhang, Jing,Chen, Yong-Jun,Zhang, Liang
experimental part, p. 3045 - 3052 (2011/09/12)
The TiCl4-catalyzed Friedel-Crafts reaction with trifluoroacetaldehyde ethyl hemiacetal is shown to serve as an efficient route for the synthesis of CF3-substitituted compounds of biological and synthetic importance, producing 2,2,2-trifluoroet
Regioselective substitution of phenols with trifluoroacetaldehyde ethyl hemiacetal
Gong,Kato,Kimoto
, p. 377 - 383 (2007/10/03)
2,2,2-Trifluoroethanols are of great interest because of their unique physical, chemical, and biological properties. Trifluoroacetaldehyde is a very efficient reagent for obtaining 2,2,2-trifluoroethanols. Because it is unavailable commercially, its hemia
Facile substitution of N,N-dimethylanilines and phenols with trifluoroacetaldehyde ethyl hemiacetal
Gong, Yuefa,Kato, Katsuya,Kimoto, Hiroshi
, p. 1403 - 1404 (2007/10/03)
2,2,2-Trifluoro-1-(N,N-dimethylaminophenyl)ethanols were easily formed in excellent yields by electrophilic substitution between N,N- dimethylanilines 1a, b and trifluoroacetaldehyde ethyl hemiacetal (TFAE). The corresponding substitution of phenols 2a-e
