246264-65-3Relevant academic research and scientific papers
Synthesis of new quinazoline-2,4(1H,3H)-dione non-nucleoside analogues of the reverse transcriptase inhibitor TNK-651
El-Brollosy, Nasser R.
, p. 358 - 361 (2008/02/11)
The synthesis is described of a series of new non-nucleoside analogues of the reverse transcriptase inhibitor TNK-651 from quinazoline-2,4(1H,3H)-diones. Compounds 2a-c were silylated and treated with benzyl chloromethyl ether in the presence of CsI to give 1-benzyloxymethylquinazoline derivatives 3a-c. Treatment of the silylated quinazolinediones 2a-c with the appropriate acetals 5a-e in the presence of TMS triflate afforded the corresponding TNK-651 analogues 6-10.
SULFONAMIDE DERIVATIVES
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, (2008/06/13)
The object is to provide a compound having matrixmetalloproteinase-13 inhibitory activity and aglycanase inhibitory activity. A compound of the following formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:{R1: H, NHOH; R2: H, optionally substituted alkyl, cycloalkyl, a group -AR6 [A: an alkylene which may be optionally interrupted by O, -S(O)m- or -N(R9); R6: a group (II), (III), (IV)X: O, S, -N(R10)-, -C(R11)(R12)-; Y: O, CO, -S(O)n-, -N(R10)-, -C(R11)(R12)-; R7, R8: H, alkyl, COOH, optionally subsituted alkyl, etc.; R9, R10, R11,R12: H, alkyl, etc.; m, n: 0 to 2]R3: H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl; R4: optionally substituted (hetero)arylene; R5: optionally substituted alkyl, optionally substituted (hetero)aryl}.
