24649-69-2

Basic information

• Product Name: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine
• Synonyms: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine
• CAS NO: 24649-69-2
• Molecular Weight: 555.609
• Mol File: 24649-69-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine(24649-69-2)
• EPA Substance Registry System: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine(24649-69-2)

Safety Data

• Hazardous Substances Data: 24649-69-2(Hazardous Substances Data)

Upstream product

• 3257-73-6 9-(2',3',5'-tri-O-benzyl-β-D-arabinofuranosyl)adenine 
• 143482-59-1 6-azido-2-fluoro-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine 
• 52522-49-3 2,3,5-tri-O-benzyl-1-(4-nitrobenzoyloxy)-D-arabinofuranose 
• 4060-34-8 2,3,5-tri-O-benzyl-α-D-arabinofuranosyl chloride 
• 700-49-2 2-fluoroadenine 
• 24880-52-2 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine 

Downstream Products

• 146-78-1 Fludarabine 

Relevant articles and documents

Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine

The reaction between 2-fluoroadenine ( 3 ) and 1,3,5-tri- O -benzyl-1- α -d-chloroarabinofuranose ( 4 ) with potassium t- amylate was evaluated in various solvents to afford 9- β -d-(2,3,5-tri- O -benzyl- arabinofuranosyl)-2-fluoroadenine ( 5 ) and the co

6-azido-2-fluoropurine, useful in the synthesis of nucleosides

This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.

Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine

A method of utilizing 9-β-D-arabinofuranosyl-2-fluoroadenine, known as 2-F-AraA (NSC 118218), in the treatment of murine leukemia and as an antiviral agent for DNA viruses, such as DNA viruses Herpes Simplex Virus Type I and Vaccinia virus grown in H.Ep-2 cells in culture. An operable dosage for utilization of 2-F-AraA is a treatment span of 1-10 days with the dosage 2-8 times per day at 8-400 mg/kg/dose. It has been further found that a single dosage on days 1, 5, and 9 based on a 10-day treatment schedule gave satisfactory results.