2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine

Base Information

• Chemical Name: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine
• CAS No.: 24649-69-2
• Molecular Formula: C₃₁H₃₀FN₅O₄
• Molecular Weight: 555.609
• Mol file: 24649-69-2.mol

Synonyms:2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine

Chemical Property of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine

There total 7 articles about 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2,3,5-tri-O-benzyl-α-D-arabinofuranosyl chloride (4060-34-8) + 2-fluoroadenine (700-49-2) → 7-β-D-(2,3,5-tri-O-benzyl-arabinofuranosyl)-2-fluoroadenine + 9-α-D-(2,3,5-tri-O-benzyl-arabinofuranosyl)-2-fluoroadenine + 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine (24649-69-2)

Guidance literature:

With calcium hydride; potassium tert-amylase; In sulfolane; tert-Amyl alcohol; at 45 ℃; for 22h;

DOI:10.1080/15257770600725960

Reference yield:

6-azido-2-fluoro-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine (143482-59-1) → 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine (24649-69-2)

Guidance literature:

With sodium borohydrid; In isopropyl alcohol;

Reference yield:

2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine (24880-52-2) → 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine (24649-69-2)

Guidance literature:

With sodium nitrite; In tetrahydrofuran;

upstream raw materials:

2,3,5-tri-O-benzyl-α-D-arabinofuranosyl chloride

2-fluoroadenine

2,3,5-tri-O-benzyl-1-(4-nitrobenzoyloxy)-D-arabinofuranose

6-azido-2-fluoro-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine

Downstream raw materials:

Fludarabine