246522-99-6

Upstream product

• 107940-08-9 (Z)-1,2-dimethoxy-1-(trimethylsilyloxy)ethylene 
• 246522-97-4 (2R/S)-3-phenyl-2-<(R)-1-phenylethylamino>propanenitrile 

Downstream Products

• 114886-83-8 methyl (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoate 
• 59554-14-2 (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 246523-03-5 methyl (2S,3R)-2-hydroxy-4-phenyl-3-<(R)-1-phenylethylamino>butanoate 

Relevant academic research and scientific papers

Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate

Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI- 272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids.