114886-83-8

Upstream product

• 75523-28-3 5-benzyl-1,2-dihydropyrazol-3-one 
• 63158-17-8 methyl (E)-4-phenyl-2-butenoate 
• 73845-38-2 methyl 4-phenylbut-2-ynoate 
• 37779-49-0 methyl 3-oxo-4-phenylbutanoate 
• 75414-69-6 methyl threo-2,3-dihydroxy-4-phenylbutanoate 
• 75414-66-3 methyl threo-3-hydroxy-2-tosyloxy-4-phenylbutanoate 
• 34541-75-8 methyl (Z)-4-phenyl-2-butenoate 
• 73845-40-6 methyl trans-2,3-epoxy-4-phenylbutanoate 
• 673-06-3 D-(R)-phenylalanine 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 129867-98-7 (R)-N-(isopropoxycarbonyl)phenylalaninal 
• 129867-99-8 (3-R)-2-acetoxy-3-isopropoxycarbonylamino-4-phenylbutyronitrile 
• 128223-47-2 (R)-N-(isopropoxycarbonyl)phenylalaninol 
• 128223-46-1 methyl (R)-N-(isopropoxycarbonyl)phenylalaninate 

Downstream Products

• 59554-14-2 (±)-(4R,5S)-4-benzyl-2-oxooxazolidine-5-carboxylic acid 
• 59554-14-2 DL-erythro-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 140409-02-5 methyl (2S,3R)-2-acetoxy-3-acetylamino-4-phenylbutyrate 
• 140409-03-6 methyl (2R,3R)-2-acetoxy-3-acetylamino-4-phenylbutyrate 
• 59554-14-2 (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 95105-20-7 (2S,3R)-3-amino-4-phenylbutane-1,2-diol 

Relevant academic research and scientific papers

Aryl imidazole derivative and application thereof

The invention relates to an aryl imidazole derivative and application thereof. The aryl imidazole derivative is a compound shown as a formula (I) in the description or pharmaceutically acceptable salt thereof. The invention also discloses application of the aryl imidazole derivative in preparation of drugs for treating cancers. The invention further discloses application of the aryl imidazole derivative in preparation of drugs for treating diseases caused by EGFR mutation.

Total synthesis of (-)-Haouamine B pentaacetate and structural revision of haouamine B

The enantiocontrolled total synthesis of (-)-haouamine B pentaacetate was accomplished via an optically active indane-fused β-lactam, which was prepared by a newly developed Friedel-Crafts reaction. Subsequent cleavage of the β-lactam and an intramolecular McMurry coupling reaction provided the core indane-fused tetrahydropyridine, which led to the elucidation of the structure, as proposed by Trauner and Zuba.

Efficient enantioselective synthesis of α-hydroxy-β-amino acids using the Claisen and Curtius rearrangements

Highly enantioselective and facile synthesis of α-hydroxy-β- amino acids has been achieved using the Claisen and Curtius rearrangements as key reactions. Chiral allylic alcohols were employed, which can be prepared by asymmetric catalysis in both E- and Z

Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate

Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI- 272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids.

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh

A Practical Synthesis of threo-3-Amino-2-hydroxycarboxylic Acids

An expeditious synthesis of (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid (2) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (4), the key components of the renin inhibitor (1) and bestatin (3), respectively, have been accomplished by featuring hi