246538-22-7

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 246538-19-2 3'-C-carbobenzyloxyamino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5'(R)-C-hydroxyethylthymidine 
• 246538-35-2 3-[(2S,3S,5R)-3-Benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propionic acid ethyl ester 
• 246538-17-0 3'-C-carbobenzyloxyamino-3'-deoxythymidine 
• 246538-34-1 [(2S,3S,5R)-2-Formyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid benzyl ester 
• 52450-18-7 3'-amino-3'-deoxythymidine 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 246538-18-1 3'-C-carbobenzyloxyamino-3'-deoxy-5'(R,S)-C-ethoxycarbonylmethylthymidine 

Downstream Products

• 246538-23-8 3'-C-amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3-N,5'(R)-C-ethylenethymidine 

Relevant academic research and scientific papers

Conformationally locked nucleosides. Synthesis and stereochemical assignments of 3'-N,5'-C-bridged 3'-amino-3'-deoxythymidines

3'-Amino-3'-deoxythymidine was converted, in multi-steps, to its 5'-O- (4,4'-dimethoxytrityl)-5'-C-tosyloxyethyl-3'-N-carbobenzoxy derivative 7 and 5'-C-mesyloxyethyl-3'-N-(9-fluorenyl)methoxycarbonyl derivatives 6 and 11. Subsequent hydrogenolysis or treatment with DMAP afforded 3'-N,5'-C-bridged bicyclic thymidines. Stereochemical assignments were accomplished with the help of NOE.