24654-48-6

Basic information

• Product Name: 4-FLUOROCINNAMONITRILE
• Synonyms: 4-FLUOROCINNAMONITRILE;3-(4-FLUOROPHENYL)-2-PROPENENITRILE;2-Propenenitrile,3-(4-fluorophenyl)-(9CI);4-FLUOROCINNAMONITRILE 99%;4-FLUOROCINNAMONITRILE, 99+%;3-(4-Fluorophenyl)acrylonitrile;(E)-3-(4-fluorophenyl)acrylonitrile
• CAS NO: 24654-48-6
• Molecular Formula: C₉H₆FN
• Molecular Weight: 147.15
• Product Categories: HALIDE;Aromatic Nitriles
• Mol File: 24654-48-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 69-70°C
• Boiling Point: 65-75°C/0.2 mm
• Flash Point: 101.6 °C
• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 0.0234mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-FLUOROCINNAMONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROCINNAMONITRILE(24654-48-6)
• EPA Substance Registry System: 4-FLUOROCINNAMONITRILE(24654-48-6)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 24654-48-6(Hazardous Substances Data)

Usage

General Description

4-FLUOROCINNAMONITRILE is a chemical compound with the molecular formula C9H6FNO. It is a white solid with a faint odor and is also known by the chemical name 3-(4-fluorophenyl)prop-2-enenitrile. 4-FLUOROCINNAMONITRILE is widely used in organic synthesis as a precursor for various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the production of fragrances and flavoring agents. 4-FLUOROCINNAMONITRILE is considered to be a hazardous substance and should be handled with appropriate safety precautions to avoid exposure and potential health risks.

InChI:InChI=1/C9H6FN/c10-9-5-3-8(4-6-9)2-1-7-11/h1-6H/b2-1+

Upstream product

• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 459-57-4 4-fluorobenzaldehyde 
• 352-34-1 4-fluoro-1-iodobenzene 
• 107-13-1 acrylonitrile 
• 75-05-8 acetonitrile 

Downstream Products

• 101488-65-7 3-(4-fluorophenyl)propan-1-amine 
• 25468-86-4 3-(4'-fluorophenyl)propanenitrile 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

Transition-metal-free Intramolecular C-H amination of sulfamate esters and: N -alkylsulfamides

The transition-metal-free intramolecular C-H amination of sulfamate esters using iodine oxidants, tert-butyl hypoiodite (t-BuOI) and N-iodosuccinimide (NIS) is reported. A method using NIS was also successfully applied to the oxidative cyclization of N-alkylsulfamides.

Method for synthesizing substituted acrylonitrile with one-pot process

The invention provides a method for synthesizing substituted acrylonitrile with a one-pot process. Beta-aryl substituted acrylonitrile is prepared from 0.01-1.0 mol of aryl substituted methanol or heterocycle substituted methanol as a raw material and a solvent adopting acetonitrile with the concentration of 0.2-2.0 mol/L under the alkaline action. In the oxygen atmosphere, a semiconductor photocatalyst is added, the mixture reacts under assistance of light illumination, and the reaction speed and the yield can be greatly increased. Raw materials for a reaction are easy to obtain, the method is simple and convenient, and the product has important application value.