246544-20-7Relevant academic research and scientific papers
Imidazoline-modified benzylimidazolines as h5-HT1D/1B serotonergic ligands
Prisinzano, Thomas,Law, Ho,Dukat, Malgorzata,Slassi, Abdelmalik,MaClean, Neil,Demchyshyn, Lidia,Glennon, Richard A.
, p. 613 - 619 (2007/10/03)
Sumatriptan, a h5-HT1D and h5-HT1B receptor agonist used clinically as a migraine-abortive, produces certain side effects thought to result from its affinity for h5-HT1B receptors. The present investigation extends our wor
Benzylamidine derivatives with serotonin receptor binding activity
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, (2008/06/13)
This invention relates to compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: STR1 wherein R 1 is selected from a group of Formula i and ii: STR2 n is 1-3; R 2 is selected from H and C 1-6 alkyl;R 3 is selected from H and C 1-6 alkyl;R 4 is selected from C 1-6 alkyl, halo, phenyl, amino and nitro;R 5 is selected from H, C 1-6 alkyl and arylalkyl;R 6 is selected from H or a alkylene group which is bonded to R 4 to form the naphthalene ring skeleton; and salts, hydrates and solvates thereof.Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of subtypes of the serotonin receptor is implicated, such as migraine.
