246847-98-3

Basic information

• Product Name: 2-Amino-5-chloro-3-fluoropyridine
• Synonyms: 2-Amino-5-chloro-3-fluoropyridine;2-Pyridinamine,5-chloro-3-fluoro-(9CI);5-Chloro-3-fluoropyridin-2-amine;2-Amino-5-chloro-3-fluoropyrid;5-Chloro-3-fluoro-2-pyridinamine;2-AMino-5-chloro-3-fluoropyridine;2-Amino-5-chloro-3-fluoropyridine 97%
• CAS NO: 246847-98-3
• Molecular Formula: C₅H₄ClFN₂
• Molecular Weight: 146.55
• EINECS: 253-700-5
• Product Categories: PYRIDINE;Amines;blocks;FluoroCompounds;Pyridines;Amines and Anilines;Heterocycles;Fluorine series
• Mol File: 246847-98-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 95-97℃
• Boiling Point: 195.929 °C at 760 mmHg
• Flash Point: 72.295 °C
• Appearance: /
• Density: 1.45 g/cm³
• Vapor Pressure: 0.409mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.72±0.49(Predicted)
• CAS DataBase Reference: 2-Amino-5-chloro-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-chloro-3-fluoropyridine(246847-98-3)
• EPA Substance Registry System: 2-Amino-5-chloro-3-fluoropyridine(246847-98-3)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-50
• Safety Statements: 36/37-38-45-61-63
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 246847-98-3(Hazardous Substances Data)

Usage

General Description

2-Amino-5-chloro-3-fluoropyridine is a chemical compound with the molecular formula C5H4ClFN2. It is a pyridine derivative with a chlorine and fluorine substituent on the 5th and 3rd carbon atoms, respectively. 2-Amino-5-chloro-3-fluoropyridine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also employed in organic synthesis as a building block for the preparation of various functionalized pyridines. Additionally, 2-Amino-5-chloro-3-fluoropyridine has potential applications in the field of medicinal chemistry and drug discovery due to its diverse biological activities and pharmacological properties. Overall, this compound is a useful and versatile chemical entity with relevance in multiple industrial and scientific applications.

InChI:InChI=1/C5H4ClFN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

Upstream product

• 248255-70-1 5-chloro-3-fluoro-2-hydrazinylpyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 

Downstream Products

• 1064783-29-4 5-chloro-3-fluoro-2-nitropyridine 
• 1033202-10-6 6-chloro-8-fluoroimidazo[1,2-a]pyridine 
• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 
• 1314514-82-3 3-fluoro-4-methyl-5-chloro-2-acetamidopyridine 

Relevant articles and documents

Preparation method of 2-amino-3-fluoropyridine

The invention discloses a preparation method of 2-amino-3-fluoropyridine, wherein 2,3-difluoro-5-chloropyridine is employed as a raw material and is subjected to an ammoniation reaction with ammonia water, and then a reduction reaction is carried out to prepare the 2-amino-3-fluoropyridine. The preparation method is less in steps, is simple in operation, employs low-cost and easy-to-obtain raw materials, has simple after treatment and high yield and is 77.5% in total yield, and is suitable for large-scale preparation.

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.