246853-45-2Relevant articles and documents
Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain
Liu, Gang,Kozmina, Natasha S.,Winn, Martin,Von Geldern, Thomas W.,Chiou, William J.,Dixon, Douglas B.,Nguyen, Bach,Marsh, Kennan C.,Opgenorth, Terry J.
, p. 3679 - 3689 (2007/10/03)
The endothelin (ET)-B receptor subtype is expressed on vascular endothelial and smooth muscle cells and mediates both vasodilation and vasoconstriction. On the basis of the pharmacophore of the previously reported ETA-specific antagonist 1, (ABT-627), we